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Article: Activation of alpha1-adrenoceptors increases firing frequency through protein kinase C in pyramidal neurons of rat visual cortex.

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Kobayashi M; Sasabe T; Shiohama Y; Koshikawa N
Neurosci. Lett., 2008


Table 1The effects of phenylephrine, isoproterenol and phorbol ester on the resting membrane potential, input resistance and properties of action potential
Resting membrane potential (mV)Input resistance (MΩ)Action potential amplitude (mV)Half-duration (ms)mAHPa amplitude (mV)Half-duration (ms)
Control−71.5±1.338.4±2.697.8±2.21.7±0.10.9±0.251.0±9.9
Phenylephrine−68.9±1.9*40.6±3.993.1±3.2*1.8±0.1**1.0±0.344.5±13.2
n302823222213
Control−71.6±1.045.6±4.7100.0±1.91.7±0.11.4±0.377.1±13.8
Isoproterenol−65.8±1.6***46.3±4.588.9±3.8***1.9±0.1**1.2±0.338.8±10.7*
n252220182011
Control−70.2±1.345.1±6.998.7±1.81.9±0.11.3±0.446.1±16.1
Phorbol ester−71.2±1.365.3±12.3*91.2±2.91.8±0.12.0±0.376.2±14.3
n13109898
aMedium-duration afterhyperpolarization.*P<0.05 (paired t-test).**P<0.01 (paired t-test).***P<0.001 (paired t-test).

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons input resistance (MΩ) 38.4 ± 2.6 (23) 38.4 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons spike amplitude from resting (mV) 97.8 ± 2.2 (23) 97.8 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons spike half-width (ms) 1.7 ± 0.1 (23) 1.7 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons medium AHP amplitude (mV) 0.9 ± 0.2 (23) 0.9 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons other (ms) 51.0 ± 9.9 (23) 51.0 (None) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons resting membrane potential (mV) -71.6 ± 1.0 (20) -71.6 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons input resistance (MΩ) 45.6 ± 4.7 (20) 45.6 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons spike amplitude from resting (mV) 100.0 ± 1.9 (20) 100.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons spike half-width (ms) 1.7 ± 0.1 (20) 1.7 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons medium AHP amplitude (mV) 1.4 ± 0.3 (20) 1.4 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons other (ms) 77.1 ± 13.8 (20) 77.1 (None) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons resting membrane potential (mV) -70.2 ± 1.3 (9) -70.2 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons input resistance (MΩ) 45.1 ± 6.9 (9) 45.1 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons spike amplitude from resting (mV) 98.7 ± 1.8 (9) 98.7 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons spike half-width (ms) 1.9 ± 0.1 (9) 1.9 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons medium AHP amplitude (mV) 1.3 ± 0.4 (9) 1.3 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons other (ms) 46.1 ± 16.1 (9) 46.1 (None) Data Table
Neocortex pyramidal cell layer 2-3 Visual Cortex Layers II/III/V Pyramidal Neurons resting membrane potential (mV) -71.5 ± 1.3 (23) -71.5 (mV) Data Table