Article: Modulation of hippocampal synaptic transmission by low concentrations of cell-permeant Ca2+ chelators: effects of Ca2+ affinity, chelator structure and binding kinetics.
Full Text (publisher's website) ;
Article Metadata ;
Article Data (extracted)
Spigelman I; Tymianski M; Wallace CM; Carlen PL; Velumian AA
Neuroscience, 1996
Table 2Effects of dimethylsulphoxide and cell-permeant chelators on postsynaptic membrane properties of CA1 neurons
DMSO EGTA BAPTA 5-N02BAPTA APTRA 4F-APTRA TPEN Pre Post Pre Post Pre Post Pre Post Pre Post Pre Post Pre Post RMP (mV) −68±1.2 −67±2.1 −68±2.0 −67±1.9 −68±1.7 −66±2.4 −67±1.5 −67±1.8 −69±2.0 −68±2.2 −68±1.4 −67±2.1 −68±1.3 −64±1.2* Ri (MΩ) 28.5±0.55 29.3±1.36 30.8±1.65 29.0±1.64 29.4±2.03 29.1±2.05 30.6±2.42 30.5±1.83 31.6±2.42 30.6±3.08 28.8±2.90 27.9±2.41 32.7±1.87 34.8±1.96 τ (ms) 12.8±1.39 11.4±1.39 11.3±0.64 9.9±0.57 12.8±0.69 11.6±0.49 12.6±1.22 11.1±0.84 12.4±0.83 10.6±0.34 12.3±0.58 10.8±0.39 12.0±0.68 10.6±0.44 Spike Vmax (V/s) 468±12.2 470±10.5 499±11.1 486±11.6 498±11.8 478±11.2 502±11.3 484±10.8 480±20.0 479±26.7 494±11.8 477±25.0 483±10.6 458±16.0 Amplitude (mV) 104±1.2 102±1.4 105±1.6 102±2.3 106±1.5 102±1.8 103±1.4 100±2.3 103±1.4 101±1.3 107±0.94 105±2.0 105±1.0 101±1.0 Duration (ms) 0.93±0.02 1.00±0.04 0.97±0.02 1.10±0.02 0.87±0.03 0.98±0.02 0.89±0.03 1.00±0.04 0.95±0.02 1.03±0.04 0.94±0.02 1.06±0.05 0.93±0.02 1.17±0.04* n 9 or 10 7–9 7–9 8 7 9 or 10 9–11
*Significant difference from DMSO controls.
Inferred neuron-electrophysiology data values
