Article: Distinguishing characteristics of serotonin and non-serotonin-containing cells in the dorsal raphe nucleus: electrophysiological and immunohistochemical studies.

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Kirby LG; Pernar L; Valentino RJ; Beck SG
Neuroscience, 2003

Table 1Electrophysiological properties of 5-HT-containing and non-5-HT-containing cells in the rat DRN

	5-HT-IR+	5-HT-IR−
Resting membrane potential (mV)	−67.8±1.4 (17)	−65.2±0.7 (20)
Input resistance (MΩ)	241.5±29.2 (15)	325.8±35.7 (20)
Tau (ms)	21.4±4.4 (16)	33.5±4.2# (20)
Spike threshold (mV)	−54.9±0.5 (17)	−54.6±0.3 (20)
Spike amplitude (mV)	61.4±2.2 (17)	65.0±2.3 (20)
Spike duration (ms)	2.0±0.1 (15)	1.8±0.1 (17)
AHP amplitude (mV)	15.9±0.9 (17)	16.6±1.4 (19)
AHP duration (t1/2; ms)	177.1±21.1 (17)	137.5±8.6 (19)
AHP tau (ms)	7.3±1.9 (17)	1.8±0.6# (19)
Firing rate of spontaneously active cells (Hz)	0.8±0.3 (3)	2.9±0.5* (5)

Values indicate mean±S.E.M. The group size is indicated within parentheses. Asterisks/pound signs indicate a significant difference between groups by unpaired Student’s t-test (*) or Mann–Whitney Rank Sum Test (#) (P<0.05). These distinguishing characteristics are further highlighted by bold print.

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Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Other	Dorsal raphe nucleus serotonergic neuron	membrane time constant (ms)	21.4 ± 4.4 (16)	21.4 (ms)	Data Table
Other	Dorsal raphe nucleus non-serotonergic neuron	membrane time constant (ms)	33.5 ± 4.2 (20)	33.5 (ms)	Data Table
Other	Dorsal raphe nucleus serotonergic neuron	spike threshold (mV)	-54.9 ± 0.5 (17)	-54.9 (mV)	Data Table
Other	Dorsal raphe nucleus non-serotonergic neuron	spike threshold (mV)	-54.6 ± 0.3 (20)	-54.6 (mV)	Data Table
Other	Dorsal raphe nucleus serotonergic neuron	spike amplitude (mV)	61.4 ± 2.2 (17)	61.4 (mV)	Data Table
Other	Dorsal raphe nucleus non-serotonergic neuron	spike amplitude (mV)	65.0 ± 2.3 (20)	65.0 (mV)	Data Table
Other	Dorsal raphe nucleus serotonergic neuron	spike width (ms)	2.0 ± 0.1 (15)	2.0 (ms)	Data Table
Other	Dorsal raphe nucleus non-serotonergic neuron	spike width (ms)	1.8 ± 0.1 (17)	1.8 (ms)	Data Table
Other	Dorsal raphe nucleus serotonergic neuron	AHP amplitude (mV)	15.9 ± 0.9 (17)	15.9 (mV)	Data Table
Other	Dorsal raphe nucleus non-serotonergic neuron	AHP amplitude (mV)	16.6 ± 1.4 (19)	16.6 (mV)	Data Table
Other	Dorsal raphe nucleus serotonergic neuron	AHP duration	177.1 ± 21.1 (17)	177.1 (ms)	Data Table
Other	Dorsal raphe nucleus non-serotonergic neuron	AHP duration	137.5 ± 8.6 (19)	137.5 (ms)	Data Table
Other	Dorsal raphe nucleus serotonergic neuron	fast AHP duration (ms)	7.3 ± 1.9 (17)	7.3 (ms)	Data Table
Other	Dorsal raphe nucleus non-serotonergic neuron	fast AHP duration (ms)	1.8 ± 0.6 (19)	1.8 (ms)	Data Table
Other	Dorsal raphe nucleus serotonergic neuron	spontaneous firing rate (Hz)	0.8 ± 0.3 (3)	0.8 (Hz)	Data Table
Other	Dorsal raphe nucleus non-serotonergic neuron	spontaneous firing rate (Hz)	2.9 ± 0.5 (5)	2.9 (Hz)	Data Table
Other	Dorsal raphe nucleus serotonergic neuron	resting membrane potential (mV)	-67.8 ± 1.4 (17)	-67.8 (mV)	Data Table
Other	Dorsal raphe nucleus non-serotonergic neuron	resting membrane potential (mV)	-65.2 ± 0.7 (20)	-65.2 (mV)	Data Table
Other	Dorsal raphe nucleus serotonergic neuron	input resistance (MΩ)	241.5 ± 29.2 (15)	241.5 (MΩ)	Data Table
Other	Dorsal raphe nucleus non-serotonergic neuron	input resistance (MΩ)	325.8 ± 35.7 (20)	325.8 (MΩ)	Data Table