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Article: The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing.

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Seif T; Makriyannis A; Kunos G; Bonci A; Hopf FW
Neuroscience, 2011


Table 1Increased firing with JZL/D1/D2 was not accompanied by a change in the action potential threshold or amplitude (suggesting no changes in sodium channel function) or input resistance (suggesting no changes in ion channels such as inwardly rectifying potassium channel and potassium leak channels that are active at the resting potential). Data are taken 8 min after addition of JZL, or 8 min after addition of D1R and D2R agonists in the presence of JZL
BaselinePost-JZLJZL+D1R+D2R
Action potential threshold (mV)−45.54±1.53−45.64±1.58−46.35±1.87
Action potential amplitude (mV)79.43±2.1379.04±2.6177.85±2.94
Input resistance (MΩ)63.17±6.2162.87±5.5363.83±6.45
JZL, JZL184.All F<1 and P>0.1.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus accumbens core neuron spike amplitude (mV) 79.43 ± 2.13 79.43 (mV) Data Table
Nucleus accumbens core neuron input resistance (MΩ) 63.17 ± 6.21 63.17 (MΩ) Data Table
Nucleus accumbens core neuron spike threshold (mV) -45.54 ± 1.53 -45.54 (mV) Data Table