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Article: Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons.

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McDermott CM; LaHoste GJ; Chen C; Musto A; Bazan NG; Magee JC
J. Neurosci., 2003


Table 1.

Somatic membrane properties of CA1 pyramidal neurons

Rat Vm (mV) Rinω (M&OHgr;) AP thresh (mV) AP ampl (mV) AP width (msec) fAHP ampl (mV) fAHP dur (msec) mAHP ampl (mV) mAHP dur (msec) Adapt (msec) Cort (ng/ml) n = 12
SP (19) -62 ± 1 52 ± 3* -51 ± 1 90 ± 5 0.8 ± 0.02 8.9 ± 2 4.1 ± 0.1 1.3 ± 0.2 249 ± 55 73 ± 8 211 ± 33*
Control (25) -63 ± 1 69 ± 3 -53 ± 1 92 ± 4 0.8 ± 0.02 8.6 ± 1 4.8 ± 0.5 1.2 ± 0.1 190 ± 36 43 ± 4* 87 ± 21
  • Vm′ Resting membrane potential; Rin′ input resistance; AP, action potential; thresh, threshold; ampl, amplitude from Vm′ width at half-maximum amplitude; fAHP ampl, fast afterhyperpolarization peak amplitude from Vm′. dur, duration at half-maximum amplitude; mAHP, medium afterhyperpolariztion; adapt, spike frequency adaptation as mean spike interval during last 350 msec of 700 msec current injection; Cort, plasma corticosterone concentration. *p<0.01.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -63.0 ± 1.0 (25) -63.0 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance 69.0 ± 3.0 (25) 69.0 (MΩ) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -53.0 ± 1.0 (25) -53.0 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude from resting (mV) 92.0 ± 4.0 (25) 92.0 (mV) Data Table
Hippocampus CA1 pyramidal cell spike half-width (msec) 0.8 ± 0.02 (25) 0.8 (ms) Data Table
Hippocampus CA1 pyramidal cell fast AHP amplitude (mV) 8.6 ± 1.0 (25) 8.6 (mV) Data Table
Hippocampus CA1 pyramidal cell fast AHP duration (msec) 4.8 ± 0.5 (25) 4.8 (ms) Data Table
Hippocampus CA1 pyramidal cell medium AHP amplitude (mV) 1.2 ± 0.1 (25) 1.2 (mV) Data Table
Hippocampus CA1 pyramidal cell medium AHP duration (msec) 190.0 ± 36.0 (25) 190.0 (ms) Data Table