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Article: Quantitative estimate of synaptic inputs to striatal neurons during up and down states in vitro.

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Blackwell KT; Czubayko U; Plenz D
J. Neurosci., 2003


Table 1.

Electrophysiological characteristics of striatal spiny projection neurons and fast spiking interneurons in cortex-striatum-substantia nigra cultures

Characteristics Spiny projection neuron (n=16) Fast spiking interneuron (n=7)
Down-state potential (mV) −79.2 ± 1.9 −64.5 ± 3.3**
Input resistance (MΩ)a 341 ± 36 287 ± 60
Spike amplitude (mV)b 61.5 ± 2.4 57.1 ± 5.0
Spike width (msec)c 1.51 ± 0.09 0.83 ± 0.05
AHPmax (mV) 14.1 ± 0.8 17.3 ± 2.0
Time to AHPmax (msec) 8.8 ± 0.4 4.8 ± 0.6**
Latency to first spike (msec)d 379 ± 25 199 ± 28

  • Results are mean ± SEM (MANOVA:F = 18.74;p = 0.001;**ANOVA on time to AHPmax:F = 33.62;p<0.0001; ANOVA on down-state potential:F = 15.03;p = 0.0019). Spike width and latency to first spike were used to classify neurons; thus, ANOVA is inappropriate on these characteristics.

  • ↵ a Measured using depolarizing and hyperpolarizing current pulses from down-state potential.

  • ↵ b Spike threshold to spike peak.

  • ↵ c Action potential width measured at half of spike amplitude.

  • ↵ d Maximal observed latency in response to 500 msec current pulses at various current strengths.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum medium spiny neuron Neostriatum spiny projection neuron spike half-width (msec) 1.51 ± 0.09 (16) 1.51 (ms) Data Table
Neostriatum gabaergic interneuron Neostriatum fast-spiking interneuron spike half-width (msec) 0.83 ± 0.05 (7) 0.83 (ms) Data Table
Neostriatum medium spiny neuron Neostriatum spiny projection neuron AHP amplitude (mV) 14.1 ± 0.8 (16) 14.1 (mV) Data Table
Neostriatum gabaergic interneuron Neostriatum fast-spiking interneuron AHP amplitude (mV) 17.3 ± 2.0 (7) 17.3 (mV) Data Table
Neostriatum medium spiny neuron Neostriatum spiny projection neuron AHP duration (msec) 8.8 ± 0.4 (16) 8.8 (ms) Data Table
Neostriatum gabaergic interneuron Neostriatum fast-spiking interneuron AHP duration (msec) 4.8 ± 0.6 (7) 4.8 (ms) Data Table
Neostriatum medium spiny neuron Neostriatum spiny projection neuron resting membrane potential (mV) -79.2 ± 1.9 (16) -79.2 (mV) Data Table
Neostriatum medium spiny neuron Neostriatum spiny projection neuron first spike latency (msec) 379.0 ± 25.0 (16) 379.0 (ms) Data Table
Neostriatum gabaergic interneuron Neostriatum fast-spiking interneuron first spike latency (msec) 199.0 ± 28.0 (7) 199.0 (ms) Data Table
Neostriatum gabaergic interneuron Neostriatum fast-spiking interneuron resting membrane potential (mV) -64.5 ± 3.3 (7) -64.5 (mV) Data Table
Neostriatum medium spiny neuron Neostriatum spiny projection neuron input resistance (MΩ) 341.0 ± 36.0 (16) 341.0 (MΩ) Data Table
Neostriatum gabaergic interneuron Neostriatum fast-spiking interneuron input resistance (MΩ) 287.0 ± 60.0 (7) 287.0 (MΩ) Data Table
Neostriatum medium spiny neuron Neostriatum spiny projection neuron spike amplitude (mV) 61.5 ± 2.4 (16) 61.5 (mV) Data Table
Neostriatum gabaergic interneuron Neostriatum fast-spiking interneuron spike amplitude (mV) 57.1 ± 5.0 (7) 57.1 (mV) Data Table