Article: Modulation of BK channels contributes to activity-dependent increase of excitability through MTORC1 activity in CA1 pyramidal cells of mouse hippocampus.

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Springer SJ; Burkett BJ; Schrader LA
Front Cell Neurosci, 2014

Table 1

Cell properties.

	Spike amp (mV)	AHP amp (mV)	Threshold (mV)	Input resistance (MΩ)	Spike number	Sag (mV)	Animal #
Control	95.2 ± 1.7	-7.9 ± 0.8	-47.3 ± 0.9	200 ± 27.8	11.8 ± 1.1	1.9 ± 0.2	18
Paxilline	93.1 ± 1.9*	-6.9 ± 0.6	-50.3 ± 0.9****	212 ± 26.6	14.8 ± 1.2****	2.3 ± 0.2
Control	85.3 ± 7.5	-6.6 ± 1.4	-49.8 ± 1.6	197.6 ± 16.8	14.0 ± 3.2	2.1 ± 0.6	5
iberiotoxin	85.8 ± 4.7	-6.7 ± 1.4	-51.6 ± 1.2	239.0 ± 27.0	22.2 ± 2.8*	2.0 ± 0.8
Control	93.2 ± 1.3	-6.8 ± 0.6	-48.5 ± 1.1	183.8 ± 10.8	15 ± 2.1	1.5 ± 0.2	13
TBS	90.3 ± 1.3**	-5.7 ± 1.0	-50.0 ± 1.3	205.5 ± 15.2**	19 ± 2.1***	1.5 ± 0.2
TBS	95.0 ± 2.3	-8.2 ± 0.5	-49.0 ± 1.0	230.0 ± 32.4	15.2 ± 2.6	3.2 ± 0.5	9
TBS + Pax	93.5 ± 2.4	-8.2 ± 0.8	-49.8 ± 1.3	243.3 ± 38.0	15.6 ± 1.7	3.3 ± 0.6
Control	95.0 ± 1.5	-10.3 ± 1.0	-46.1 ± 1.3	180.0 ± 12.6	12.3 ± 2.1	2.4 ± 0.2	6
Rapamycin	91.5 ± 2.5	-7.4 ± 0.9***	-49.7 ± 1.1**	186.8 ± 11.6	15.5 ± 2.6**	2.4 ± 0.3
TBS+Pax	98.7 ± 2.1	-9.8 ± 1.0	-48.5 ± 1.0	227.3 ± 24	17.2 ± 3.5	3.4 ± 0.5	12
TBS+Pax + Rap	96.4 ± 1.8	-8.6 ± 1.4	-49.7 ± 1.8	233.3 ± 27.0	20.1 ± 3.9*	3.1 ± 0.5

The basic properties of cells from each group. The experimental group and its control are in one shaded group. The data are reported as mean ± SEM. The cell numbers are reported in the text. (*P < 0.05, **p < 0.01; ****p < 0.0001, all values are experimental compared to the control for that group, Students paired t-test).

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Inferred neuron-electrophysiology data values

Neuron Type	Ephys Prop	Extracted Value	Standardized Value	Content Source
Hippocampus CA1 pyramidal cell	spike amplitude (mV)	85.3 ± 7.5 (5)	85.3 (mV)	Data Table
Hippocampus CA1 pyramidal cell	AHP amplitude (mV)	-6.6 ± 1.4 (5)	6.6 (mV)	Data Table
Hippocampus CA1 pyramidal cell	spike threshold (mV)	-49.8 ± 1.6 (5)	-49.8 (mV)	Data Table
Hippocampus CA1 pyramidal cell	spike amplitude (mV)	95.2 ± 1.7 (18)	95.2 (mV)	Data Table
Hippocampus CA1 pyramidal cell	input resistance (MΩ)	197.6 ± 16.8 (5)	197.6 (MΩ)	Data Table
Hippocampus CA1 pyramidal cell	sag amplitude (mV)	2.1 ± 0.6 (5)	2.1 (mV)	Data Table
Hippocampus CA1 pyramidal cell	AHP amplitude (mV)	-7.9 ± 0.8 (18)	7.9 (mV)	Data Table
Hippocampus CA1 pyramidal cell	spike amplitude (mV)	93.2 ± 1.3 (13)	93.2 (mV)	Data Table
Hippocampus CA1 pyramidal cell	AHP amplitude (mV)	-6.8 ± 0.6 (13)	6.8 (mV)	Data Table
Hippocampus CA1 pyramidal cell	spike threshold (mV)	-48.5 ± 1.1 (13)	-48.5 (mV)	Data Table
Hippocampus CA1 pyramidal cell	input resistance (MΩ)	183.8 ± 10.8 (13)	183.8 (MΩ)	Data Table
Hippocampus CA1 pyramidal cell	sag amplitude (mV)	1.5 ± 0.2 (13)	1.5 (mV)	Data Table
Hippocampus CA1 pyramidal cell	spike threshold (mV)	-47.3 ± 0.9 (18)	-47.3 (mV)	Data Table
Hippocampus CA1 pyramidal cell	input resistance (MΩ)	200.0 ± 27.8 (18)	200.0 (MΩ)	Data Table
Hippocampus CA1 pyramidal cell	spike amplitude (mV)	95.0 ± 1.5 (6)	95.0 (mV)	Data Table
Hippocampus CA1 pyramidal cell	AHP amplitude (mV)	-10.3 ± 1.0 (6)	10.3 (mV)	Data Table
Hippocampus CA1 pyramidal cell	spike threshold (mV)	-46.1 ± 1.3 (6)	-46.1 (mV)	Data Table
Hippocampus CA1 pyramidal cell	input resistance (MΩ)	180.0 ± 12.6 (6)	180.0 (MΩ)	Data Table
Hippocampus CA1 pyramidal cell	sag amplitude (mV)	2.4 ± 0.2 (6)	2.4 (mV)	Data Table
Hippocampus CA1 pyramidal cell	sag amplitude (mV)	1.9 ± 0.2 (18)	1.9 (mV)	Data Table