Article: In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome.

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Wang T; de Kok L; Willemsen R; Elgersma Y; Borst JG
Front Cell Neurosci, 2015

Table 1

Analysis of complex waveforms and STP in four different mouse models for neuropsychiatric disorders.

	Prespike-eAP delay (ms)	eEPSP-eAP delay (ms)	eAP half width (ms)	Spontaneous frequency (Hz)	Maximum evoked frequency (Hz)	Steady state firing frequency (Hz)	Spontaneous failures (%)	Facilitation	STD (Relative eEPSP’)	Depression τ (number of events)	Recovery τ (ms)
Tsc1^+/+	0.55 ± 0.02	0.2 ± 0.01	0.26 ± 0.01	21 ± 3	245 ± 32	131 ± 18	0.01 ± 0.01	1.06 ± 0.01	0.84 ± 0.02	6 ± 0.5	207 ± 74
Tsc1^+/^-	0.68 ± 0.04	0.25 ± 0.03	0.26 ± 0.02	30 ± 9	288 ± 32	148 ± 19	8.28 ± 6.32	1.07 ± 0.03	0.78 ± 0.05	6.6 ± 1.4	274 ± 91
Fmr1 WT	0.65 ± 0.02	0.25 ± 0.02	0.27 ± 0.01	23 ± 5	303 ± 22	159 ± 9	2.31 ± 2.28	1.07 ± 0.01	0.81 ± 0.03	6.4 ± 0.7	177 ± 43
Fmr1 KO	0.65 ± 0.03	0.23 ± 0.01	0.26 ± 0.01	27 ± 6	282 ± 24	145 ± 12	0.17 ± 0.12	1.08 ± 0.02	0.76 ± 0.03	6.6 ± 0.6	245 ± 96
Nf1^+/+	0.72 ± 0.04	0.25 ± 0.02	0.25 ± 0.01	16 ± 5	326 ± 11	151 ± 6	8.12 ± 5.77	1.15 ± 0.04	0.67 ± 0.04	4.9 ± 0.3	227 ± 46
Nf1^+/^-	0.63 ± 0.03	0.18 ± 0.01^∗	0.22 ± 0.01	37 ± 12	305 ± 17	162 ± 12	0.85 ± 0.85	1.14 ± 0.03	0.75 ± 0.04	5 ± 0.6	219 ± 60
Hras WT	0.72 ± 0.04	0.23 ± 0.02	0.26 ± 0.02	40 ± 7	302 ± 17	155 ± 12	1.68 ± 1.47	1.1 ± 0.03	0.78 ± 0.04	4.9 ± 0.4	156 ± 74
Hras^G12V	0.76 ± 0.05	0.24 ± 0.02	0.22 ± 0.01	36 ± 10	261 ± 14	135 ± 12	3.86 ± 2.21	1.13 ± 0.05	0.82 ± 0.03	6.2 ± 0.8	155 ± 74

Different parameters were quantified in in vivo recordings from Tsc1^+/-, Fmr1 KO, Nf1^+/-, and H-ras^G12V mutant mice and their respective wild-type (WT) littermates (n = 12 for Tsc1 WT and n = 9 for Tsc1^+/-; n = 26 for Fmr1 WT and n = 18 for Fmr1 KO; n = 13 for Nf1 WT and n = 10 for Nf1^+/-; n = 10 for H-ras WT and n = 9 for H-ras^G12V). Data is presented as mean ± SEM. * indicates significant difference in pair-wise post hoc t-test comparison.

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Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Medial Nucleus of Trapezoid Body neuron	Medial nucleus of the trapezoid body calyx of Held synapse neuron	spontaneous firing rate (Hz)	23.0 ± 5.0 (26)	23.0 (Hz)	Data Table
Medial Nucleus of Trapezoid Body neuron	Medial nucleus of the trapezoid body calyx of Held synapse neuron	maximum firing rate (Hz)	303.0 ± 22.0 (26)	303.0 (Hz)	Data Table
Medial Nucleus of Trapezoid Body neuron	Medial nucleus of the trapezoid body calyx of Held synapse neuron	firing frequency (Hz)	159.0 ± 9.0 (26)	159.0 (Hz)	Data Table
Medial Nucleus of Trapezoid Body neuron	Medial nucleus of the trapezoid body calyx of Held synapse neuron	spontaneous firing rate (Hz)	16.0 ± 5.0 (13)	16.0 (Hz)	Data Table
Medial Nucleus of Trapezoid Body neuron	Medial nucleus of the trapezoid body calyx of Held synapse neuron	maximum firing rate (Hz)	326.0 ± 11.0 (13)	326.0 (Hz)	Data Table
Medial Nucleus of Trapezoid Body neuron	Medial nucleus of the trapezoid body calyx of Held synapse neuron	firing frequency (Hz)	151.0 ± 6.0 (13)	151.0 (Hz)	Data Table
Medial Nucleus of Trapezoid Body neuron	Medial nucleus of the trapezoid body calyx of Held synapse neuron	spontaneous firing rate (Hz)	21.0 ± 3.0 (12)	21.0 (Hz)	Data Table
Medial Nucleus of Trapezoid Body neuron	Medial nucleus of the trapezoid body calyx of Held synapse neuron	maximum firing rate (Hz)	245.0 ± 32.0 (12)	245.0 (Hz)	Data Table
Medial Nucleus of Trapezoid Body neuron	Medial nucleus of the trapezoid body calyx of Held synapse neuron	spontaneous firing rate (Hz)	40.0 ± 7.0 (10)	40.0 (Hz)	Data Table
Medial Nucleus of Trapezoid Body neuron	Medial nucleus of the trapezoid body calyx of Held synapse neuron	maximum firing rate (Hz)	302.0 ± 17.0 (10)	302.0 (Hz)	Data Table
Medial Nucleus of Trapezoid Body neuron	Medial nucleus of the trapezoid body calyx of Held synapse neuron	firing frequency (Hz)	131.0 ± 18.0 (12)	131.0 (Hz)	Data Table
Medial Nucleus of Trapezoid Body neuron	Medial nucleus of the trapezoid body calyx of Held synapse neuron	firing frequency (Hz)	155.0 ± 12.0 (10)	155.0 (Hz)	Data Table