Article: Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Kobayashi M; Buckmaster PS J. Neurosci., 2003
Control | n (cells) | Epileptic | n(cells) | |
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Input resistance (MΩ) | 102 ± 8 | 37 | 110 ± 11 | 26 |
Resting membrane potential (mV) | −77 ± 1 | 37 | −76 ± 2 | 26 |
Normal ACSF | ||||
Stimulation intensity (mA) | 0.34 ± 0.04 | 33 | 0.35 ± 0.05 | 25 |
20 msec latency | ||||
Conductance (nS) | 26.5 ± 2.2 | 33 | 19.7 ± 3.9 | 25 |
Reversal potential (mV) | −60 ± 1 | 33 | −51 ± 21-165 | 25 |
150 msec latency | ||||
Conductance (nS) | 9.8 ± 0.8 | 33 | 7.5 ± 1.0 | 25 |
Reversal potential (mV) | −91 ± 1 | 33 | −91 ± 2 | 25 |
CNQX/d-APV | ||||
Stimulation intensity (mA) | 2.88 ± 1.20 | 8 | 5.28 ± 1.24 | 9 |
20 msec latency | ||||
Conductance (nS) | 44.1 ± 15.3 | 8 | 10.2 ± 1.7* | 9 |
Reversal potential (mV) | −71 ± 2 | 8 | −67 ± 1 | 9 |
150 msec latency | ||||
Conductance (nS) | 16.1 ± 3.3 | 8 | 5.2 ± 1.01-160 | 9 |
Reversal potential (mV) | −90 ± 2 | 8 | −92 ± 3 | 9 |
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Stimulation of the outer molecular layer was set at an intensity that evoked a maximum amplitude IPSP at a 150 msec latency. Stimulation intensity was reset after switching to CNQX/d-APV. Synaptic responses were measured at latencies of 20 and 150 msec, which are near the peaks of the early and late IPSPs, respectively. Values represent mean ± SEM.
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↵* p < 0.03;
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↵F1-160 p < 0.005;
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↵F1-165 p< 0.001; unpaired t test.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Dentate gyrus granule cell | input resistance (MΩ) | 102.0 ± 8.0 (37) | 102.0 (MΩ) | Data Table | |
Dentate gyrus granule cell | resting membrane potential (mV) | -77.0 ± 1.0 (37) | -77.0 (mV) | Data Table |