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Article: Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy.

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Kobayashi M; Buckmaster PS
J. Neurosci., 2003


Table 2.

Properties of fast- and slow-rising GABAAreceptor-mediated mIPSCs

Adult control  Epileptic Young control 3–7 d post-status
Number of cells 12 16 15 30
Fast-rising mIPSCs
 10–90% rise time (msec) 0.89 ± 0.06 0.86 ± 0.05 0.93 ± 0.07 0.84 ± 0.04
 Proportion 0.29 ± 0.03 0.30 ± 0.01 0.27 ± 0.02 0.33 ± 0.03
 Amplitude (pA) 10.9 ± 1.12-159 19.8 ± 3.72-167,* 10.7 ± 0.92-159 17.1 ± 1.32-159,2-160
Slow-rising mIPSCs
 10–90% rise time (msec) 2.11 ± 0.08 2.17 ± 0.11 2.02 ± 0.14 2.05 ± 0.09
 Proportion 0.71 ± 0.03 0.70 ± 0.01 0.73 ± 0.02 0.67 ± 0.03
 Amplitude (pA) 8.8 ± 0.7 9.9 ± 0.5 9.2 ± 0.7 11.3 ± 0.6*

  • Histograms of mIPSC rise times from individual cells were fit with two Gaussian curves (Fig. 8 e). From the two Gaussian curves, the average rise times of fast-rising and slow-rising events were calculated. Those results were compiled for cells from animals in all four experimental groups, and the values in this Table represent the means ± SEM. There were no significant differences in the average rise times or proportion of fast- versus slow-rising events between epileptic, 3–7 d post-status epilepticus, and control rats (t test). Average amplitudes of the fastest fast-rising (10–90% rise time less than the median minus 1 SD) and the slowest slow-rising (10–90% rise time more than the median plus 1 SD) were calculated and are shown in this Table. Within each experimental group, the average amplitudes of the fastest fast-rising mIPSCs were larger than the average amplitudes of the slowest slow-rising mIPSCs (

  • ↵F2-159 p < 0.05;

  • ↵F2-167 p < 0.001; paired ttest). The average amplitude of the fastest fast-rising mIPSCs in epileptic rats was 182% of that of adult controls (

  • ↵* p < 0.05; unpaired t test). Similarly, the average amplitude of the fastest fast-rising mIPSCs in 3–7 d post-status epilepticus rats was 160% of that of young controls (

  • ↵F2-160 p < 0.001; unpaired t test). The average amplitude of the slowest slow-rising mIPSCs in 3–7 d post-status epilepticus rats was 123% of that of young controls (*p < 0.05; unpaired ttest).


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