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Article: Activity-dependent serotonergic excitation of callosal projection neurons in the mouse prefrontal cortex.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Stephens EK; Avesar D; Gulledge AT Front Neural Circuits, 2014
Properties of L5PN subtypes and their responses to serotonin.
| L5PN subtype | RMP (mV) | RN (MΩ) | Sag (%) | Response property | With DC-current | At RMP | |
|---|---|---|---|---|---|---|---|
| COM-excited | 13 | -77 ± 2 | 188 ± 13 | 6 ± 1 | Peak increase in spike frequency (%) or peak depolarization (mV) | 119 ± 15 | 3.3 ± 0.2 |
| Time to peak excitation (s) | 11 ± 1 | 28 ± 3* | |||||
| COM-biphasic | 6 | -78 ± 2 | 173 ± 30 | 4 ± 1 | Peak increase in spike frequency (%) | 87 ± 13 | N/A |
| Duration of inhibition (s) | 18 ± 3 | 25 ± 4* | |||||
| Time to peak hyperpolarization (s) | 11 ± 2 | 7 ± 1 | |||||
| CPn | 9 | -78 ± 1 | 77 ± 7 | 13 ± 1 | Duration of inhibition (s) | 37 ± 2 | 28 ± 4* |
| Time to peak hyperpolarization (s) | 6 ± 0.3 | 5 ± 0.4 | |||||
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neocortex pyramidal cell layer 5-6 | Prefrontal cortex layer 5 corticocortical pyramidal neuron with biphasic response to serotonin | resting membrane potential (mV) | -78.0 ± 2.0 (6) | -78.0 (mV) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Prefrontal cortex layer 5 corticocortical pyramidal neuron with biphasic response to serotonin | input resistance (MΩ) | 173.0 ± 30.0 (6) | 173.0 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Prefrontal cortex layer 5 corticocortical pyramidal neuron with biphasic response to serotonin | sag ratio | 4.0 ± 1.0 (6) | 0.04 (ratio) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Prefrontal cortex layer 5 corticocortical pyramidal neuron with excitatory response to serotonin | resting membrane potential (mV) | -77.0 ± 2.0 (13) | -77.0 (mV) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Prefrontal cortex layer 5 corticocortical pyramidal neuron with excitatory response to serotonin | input resistance (MΩ) | 188.0 ± 13.0 (13) | 188.0 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Prefrontal cortex layer 5 corticopontine pyramidal neuron | resting membrane potential (mV) | -78.0 ± 1.0 (9) | -78.0 (mV) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Prefrontal cortex layer 5 corticopontine pyramidal neuron | input resistance (MΩ) | 77.0 ± 7.0 (9) | 77.0 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Prefrontal cortex layer 5 corticopontine pyramidal neuron | sag ratio | 13.0 ± 1.0 (9) | 0.13 (ratio) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Prefrontal cortex layer 5 corticocortical pyramidal neuron with excitatory response to serotonin | sag ratio | 6.0 ± 1.0 (13) | 0.06 (ratio) | Data Table |