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Article: Afterhyperpolarization regulates firing rate in neurons of the suprachiasmatic nucleus.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Cloues RK; Sather WA J. Neurosci., 2003
Table 2.
Effect of blockers of Ca2+ channels and of KCa channels on membrane properties of cluster I SCN neurons
| Control | Cd2+ | ω-CTx-GVIA | ω-Aga-IVA | Nimodipine | Mibefradil | Ni2+ | ICamixture | Apamin | Iberiotoxin | |
|---|---|---|---|---|---|---|---|---|---|---|
| Number of neurons (n) | 60 | 10 | 6 | 6 | 6 | 6 | 6 | 8 | 6 | 6 |
| Interspike potential (mV) | −41 ± 0.8 | −41 ± 1.6 | −37 ± 1.9 | −38 ± 1.4 | −39 ± 2.7 | −40 ± 1.3 | −37 ± 2.1 | −38 ± 2.6 | −41 ± 1.5 | −37 ± 3.1 |
| Spike amplitude (mV) | 75 ± 1.7 | 60 ± 4.72-160 | 69 ± 1.8 | 71 ± 5.2 | 75 ± 4.5 | 81 ± 4.9 | 78 ± 5.1 | 72 ± 4.3 | 80 ± 3.5 | 73 ± 6.2 |
| Spike width (msec) | 2.4 ± 0.1 | 4.2 ± 0.52-160 | 3.1 ± 0.2* | 3.0 ± 0.3 | 2.6 ± 0.3 | 2.3 ± 0.2 | 2.4 ± 0.2 | 3.6 ± 0.42-160 | 2.4 ± 0.2 | 4.0 ± 0.42-160 |
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Membrane properties were measured as described in Table 1. Concentrations of blockers used are as given in Materials and Methods. I Ca blocker mixture represents the combination of 10 μm nimodipine, 3 μmω-CTx-GVIA, 200 nm ω-Aga-IVA, 30 μmNi2+, and 500 nm mibefradil.
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↵* p < 0.05,
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↵F2-160 p < 0.01, compared with control.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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