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Article: Delayed mesolimbic system alteration in a developmental animal model of schizophrenia.

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Goto Y; O'Donnell P
J. Neurosci., 2002


Table 1.

In vivo electrophysiological properties of NAcc neurons

>P56 P28–P35 Adult lesion Haloperidol, neonatal VH lesion Vehicle, neonatal VH lesion
Neonatal VH lesion Neonatal sham Neonatal VH lesion Neonatal sham Adult VH lesion Adult sham
Number of up/down cells/total recorded 10/14 6/8 6/8 4/6 1/10 7/11 27/35 7/7
Percentage 71% 75% 75% 67% 10%1-a 64% 77% 100%
Membrane potential (mV)
 Down −74.1  ± 12.0 −78.8  ± 9.0 −65.1  ± 6.9 −62.8  ± 5.7 −76.0  ± 7.4 −75.1  ± 10 −77.5  ± 7.3 −78.1  ± 5.5
 Up −67.3  ± 11.3 −60.8  ± 12.9 −56.9  ± 4.2 −56.3  ± 8.0 — −65.0  ± 6.6 −65.3  ± 8.8 −67.7  ± 8.1
Input resistance (MΩ) 43.4  ± 13.4 37.3  ± 16.1 27.8  ± 14.2 44.5  ± 11.7 38.4  ± 18.3 48.6  ± 16.5 46.6  ± 20.1 48.4  ± 12.4
Time constant (msec) 6.0  ± 1.9 6.5  ± 2.4 5.0  ± 1.7 6.5  ± 2.3 4.9  ± 0.6 6.7  ± 1.3 6.5  ± 2.3 6.8  ± 3.5
Up frequency (Hz) 0.49  ± 0.21 0.81  ± 0.13 0.67  ± 0.37 0.59  ± 0.10 — 0.64  ± 0.31 0.49  ± 0.21 0.81  ± 0.13
Up duration (msec) 357  ± 182 605  ± 199 210  ± 134 168  ± 136 — 359  ± 239 510  ± 310 287  ± 141
Firing rate (Hz) 1.46  ± 0.84 0.51  ± 0 1.74  ± 2.07 1.58  ± 0.87 — 2.61  ± 2.08 2.12  ± 2.27 0  ± 0
(n  = 4/14)1-b (n  = 1/8) (n  = 3/8) (n  = 3/6) 1-c — (n  = 3/11) (n  = 8/35) (n  = 0/7)

  • All values are mean ± SD.

  • ↵F1-a Fisher's exact test compared with neonatal VH lesion at >P56 (p = 0.0042); compared with adult sham (p = 0.017).

  • ↵F1-b Number of cells that showed spontaneous spike firing.

  • ↵F1-c Unpaired t test compared with vehicle (p < 0.00001).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Nucleus Accumbens VH-Nucleus Accumbens neuron resting membrane potential -78.8 ± 9.0 -78.8 (mV) Data Table
Other Nucleus Accumbens VH-Nucleus Accumbens neuron resting membrane potential -62.8 ± 5.7 -62.8 (mV) Data Table
Other Nucleus Accumbens VH-Nucleus Accumbens neuron resting membrane potential -75.1 ± 10.0 -75.1 (mV) Data Table
Other Nucleus Accumbens VH-Nucleus Accumbens neuron input resistance (MΩ) 37.3 ± 16.1 37.3 (MΩ) Data Table
Other Nucleus Accumbens VH-Nucleus Accumbens neuron input resistance (MΩ) 44.5 ± 11.7 44.5 (MΩ) Data Table
Other Nucleus Accumbens VH-Nucleus Accumbens neuron input resistance (MΩ) 48.6 ± 16.5 48.6 (MΩ) Data Table
Other Nucleus Accumbens VH-Nucleus Accumbens neuron membrane time constant (msec) 6.5 ± 2.4 6.5 (ms) Data Table
Other Nucleus Accumbens VH-Nucleus Accumbens neuron membrane time constant (msec) 6.5 ± 2.3 6.5 (ms) Data Table
Other Nucleus Accumbens VH-Nucleus Accumbens neuron membrane time constant (msec) 6.7 ± 1.3 6.7 (ms) Data Table
Other Nucleus Accumbens VH-Nucleus Accumbens neuron firing frequency (Hz) 0.51 0.51 (Hz) Data Table
Other Nucleus Accumbens VH-Nucleus Accumbens neuron firing frequency (Hz) 1.58 ± 0.87 1.58 (Hz) Data Table
Other Nucleus Accumbens VH-Nucleus Accumbens neuron firing frequency (Hz) 2.61 ± 2.08 2.61 (Hz) Data Table