Article: Excitability of jcBNST neurons is reduced in alcohol-dependent animals during protracted alcohol withdrawal.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Szücs A; Berton F; Sanna PP; Francesconi W PLoS ONE, 2012
Cell type | N | Resting Vm mV | Resistance MΩ | Sag slope mV/nA | Rheobase pA | I-N slope pA-1 | Spike thresh. mV |
I Cont | 20 | -61.4±0.7 [-65.9 : -51.1] II, III | 337±31 [147 : 566] III | -38.7±3.9 [-80.2 : -17.5] II | 56.7±7.1 [15 : 117] II, III | 106±13 [35 : 226] III | -35.0±0.8 [-41.3 : -27.8] II |
I EtOH | 12 | -61.7±1.4 [-73.2 : -54.8] II, III | 353±28 [204 : 563] III | -41.5±5.2 [-89.4 : -24.9] II | 50.9±7.7 [30 : 127] II, III | 95±13 [16 : 171] | -37.0±0.9 [-44.4 : -34.1] |
II Cont | 18 | -56.8±0.7 [-61.3 : -50.6] I, III | 399±33 [192 : 664] III | 30.9±4.1 [2 : 65] I, III | 126±26 [54 : 514] | -38.2±0.6 [-44.0 : -33.6] I, III | |
II EtOH | 10 | -55.3±1.2 [-60.5 : -48.9] I, III | 427±36 [258 : 608] III | 27.8±3.8 [10 : 45] I, III | 167±29 [42 : 305] | -36.2±0.9 [-39.9 : -30.7] | |
III Cont | 31 | -72.0±0.9 [-81.6 : -57.2] I,II | 218±20 [72 : 536] I, II | N/A | 119.8±9.0 [29 : 219] I, II | 164±12 [71 : 312] I | -35.0±0.7 [-42.1 : -27.4] II |
III EtOH | 16 | -74.2±0.8 [-80.6 : -70.2] I, II | 223±23 [59 : 389] I, II | N/A | 115.8±13.8 [58 : 248] I, II | 183±31 [63 : 444] | -35.1±0.7 [-40.3 : -31.3] |
Values are expressed as means ± SEM. The sample minimum and maximum are shown in brackets. Cell type labels under the values represent statistically significant differences from the corresponding types either in control or EtOH groups. Values marked in bold-italic represent significant differences between parameters of control and EtOH cells belonging to the same type. One-way ANOVA with Bonferroni test for means comparison was used for the parameters of the three types of cells from either the control or EtOH groups. Two-sample t-tests were performed for control-EtOH comparison of identical types of neurons (p = 0.05, numbers of cells are shown under N).