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Article: Heterogeneity in the basic membrane properties of postnatal gonadotropin-releasing hormone neurons in the mouse.

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Sim JA; Skynner MJ; Herbison AE
J. Neurosci., 2001


Table 1.

Summary of intrinsic properties of GnRH neurons recorded in juvenile and adult female mice

Juvenile mice (n= 31) Adult female mice
All adult mice (n= 44) Estrous mice (n = 17) Diestrous mice (n = 27)
Resting membrane potential (mV)  −65.4 ± 1.5  −69.2 ± 1.1 −68.6  ± 2.1 −69.1  ± 1.2
  (−47 to −85)  (−52 to −85)
Input resistance (GΩ)     1.1 ± 0.2    1.5 ± 0.1 1.6  ± 0.2 1.4  ± 0.1
  (0.03–2.8)   (0.36–3.18)
Membrane time constant (msec)    39.0 ± 4.4   44.8 ± 3.5 45.5  ± 4.1 43.5  ± 5.0
    (3.0–91.1)   (12.1–110.3)
Threshold potential of spike (mV)  −39.7 ± 1.7  −33.9 ± 2.9 −36.0  ± 0.7 −38.5  ± 1.6
(−25.5 to −50.3) (−27.7 to −51.8)
Amplitude of spike (mV)   83.1 ± 2.8    84.2 ± 1.8 85.2  ± 3.2 83.6  ± 2.1
  (54.0–101.3)    (67.4–121.3)
Overshoot of spike (mV)   18.5 ± 2.0    15.4 ± 2.2 18.3  ± 4.2 13.5  ± 2.4
 (−2.1 to 33.9)  (−4.5 to 49.5)
Duration of spike (msec)    1.8 ± 0.1     2.0 ± 0.1 1.6  ± 0.1 2.3  ± 0.1*
   (1.2–2.8)     (0.8–3.4)
  • The numbers of GnRH neurons analyzed are given in parentheses. Adult GnRH neurons are further divided to show their properties in estrous and diestrous mice. A significant (* p < 0.05) difference in the duration of their action potential values was detected. Values are mean ± SEM, whereas ranges of values obtained are shown in parentheses.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other hypothalamus gonadotropin-releasing hormone neuron input resistance (GΩ) 1.1 ± 0.2 (31) 1100.0 (MΩ) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron input resistance (GΩ) 1.5 ± 0.1 (44) 1500.0 (MΩ) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron membrane time constant (msec) 39.0 ± 4.4 (31) 39.0 (ms) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron membrane time constant (msec) 44.8 ± 3.5 (44) 44.8 (ms) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron resting membrane potential (mV) -65.4 ± 1.5 (31) -65.4 (mV) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron spike threshold (mV) -39.7 ± 1.7 (31) -39.7 (mV) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron spike threshold (mV) -33.9 ± 2.9 (44) -33.9 (mV) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron resting membrane potential (mV) -69.2 ± 1.1 (44) -69.2 (mV) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron spike amplitude from resting (mV) 83.1 ± 2.8 (31) 83.1 (mV) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron spike amplitude from resting (mV) 84.2 ± 1.8 (44) 84.2 (mV) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron spike peak (mV) 18.5 ± 2.0 (31) 18.5 (mV) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron spike peak (mV) 15.4 ± 2.2 (44) 15.4 (mV) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron spike width (msec) 1.8 ± 0.1 (31) 1.8 (ms) Data Table
Other hypothalamus gonadotropin-releasing hormone neuron spike width (msec) 2.0 ± 0.1 (44) 2.0 (ms) Data Table