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Article: Intrinsic membrane properties underlying spontaneous tonic firing in neostriatal cholinergic interneurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Bennett BD; Callaway JC; Wilson CJ J. Neurosci., 2000
Effects of blocking I h, calcium, BK, or SK channels
| Firing rate (Hz) | Coefficient of variation (CV) | Vm mean (mV) | Spike threshold (mV) | Spike width (msec) | AHP amplitude (mV) | AHP time-to-peak (msec) | |
|---|---|---|---|---|---|---|---|
| Control | 1.99 ± 1.11 | 0.19 ± 0.10 | −63.9 ± 3.7 | −50.1 ± 3.3 | 2.4 ± 0.2 | 18.4 ± 3.3 | 60.5 ± 12.3 |
| Cesium | 0.61 ± 1.05 | 0.87 ± 0.58 | −69.9 ± 7.2 | −48.6 ± 3.3 | 2.4 ± 0.3 | 18.3 ± 4.2 | 60.0 ± 10.8 |
| (n = 9)* | (n = 5) | (n = 13)* | (n = 10) | (n = 10) | (n = 10) | (n = 10) | |
| Control | 1.52 ± 1.30 | 0.21 ± 0.11 | −62.6 ± 3.4 | −49.8 ± 3.0 | 2.2 ± 0.4 | 19.2 ± 2.5 | 54.6 ± 14.9 |
| Cadmium or cobalt | 0.29 ± 0.61 | 1.88 ± 0.88 | −66.6 ± 4.5 | −47.5 ± 3.2 | 1.3 ± 0.2 | 10.2 ± 3.3 | 2.4 ± 1.0 |
| (n = 14; 7, 7)* | (n = 4; 4, 0) | (n = 20; 13, 7)* | (n = 16; 9, 7)* | (n = 16; 9, 7)* | (n = 16; 9, 7)* | (n = 15; 9, 6)* | |
| Control | 3.47 ± 2.18 | 0.24 ± 0.12 | −63.6 ± 3.5 | −50.2 ± 2.3 | 2.1 ± 0.2 | 18.3 ± 5.6 | 48.5 ± 16.3 |
| TEA or IBTX | 4.53 ± 3.08 | 0.35 ± 0.26 | −62.3 ± 3.8 | −49.1 ± 2.8 | 2.7 ± 0.4 | 16.8 ± 5.7 | 44.0 ± 17.4 |
| (n = 4; 3, 1) | (n = 4; 3, 1) | (n = 7; 5, 2) | (n = 7; 5, 2) | (n = 7; 5, 2)* | (n = 7; 5, 2) | (n = 7; 5, 2) | |
| Control | 2.33 ± 1.69 | 0.29 ± 0.15 | −58.7 ± 4.7 | −49.1 ± 3.3 | 3.0 ± 0.4 | 15.6 ± 4.6 | 51.9 ± 13.0 |
| Apamin | 2.04 ± 0.88 | 0.84 ± 0.33 | −57.0 ± 4.6 | −47.4 ± 4.3 | 3.4 ± 0.5 | 7.9 ± 2.7 | 28.3 ± 22.9 |
| (n = 7) | (n = 5) | (n = 9) | (n = 6) | (n = 6)* | (n = 6)* | (n = 4) |
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All values were calculated as described in Materials and Methods, with V m mean representing the mean subthreshold membrane potential. Within group comparisons were made using the paired-sample t test for all data sets, except the coefficient of variation. The values in parentheses are the number of neurons examined in each group, with significant (p < 0.005) differences indicated by an asterisk. For experiments involving blockade of calcium or BK channels, values of n are followed by two additional numbers, which indicate the number of neurons treated with cadmium or cobalt and TEA or iberiotoxin (IBTX), respectively.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neostriatum cholinergic cell | Neostriatum cholinergic interneuron | firing frequency (Hz) | 1.99 ± 1.11 (10) | 1.99 (Hz) | Data Table |
| Neostriatum cholinergic cell | Neostriatum cholinergic interneuron | resting membrane potential (mV) | -63.9 ± 3.7 (10) | -63.9 (mV) | Data Table |
| Neostriatum cholinergic cell | Neostriatum cholinergic interneuron | spike threshold (mV) | -50.1 ± 3.3 (10) | -50.1 (mV) | Data Table |
| Neostriatum cholinergic cell | Neostriatum cholinergic interneuron | spike width (msec) | 2.4 ± 0.2 (10) | 2.4 (ms) | Data Table |
| Neostriatum cholinergic cell | Neostriatum cholinergic interneuron | AHP amplitude (mV) | 18.4 ± 3.3 (10) | 18.4 (mV) | Data Table |
| Neostriatum cholinergic cell | Neostriatum cholinergic interneuron | AHP duration (msec) | 60.5 ± 12.3 (10) | 60.5 (ms) | Data Table |