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Article: Blockade of neuronal activity during hippocampal development produces a chronic focal epilepsy in the rat.

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Galvan CD; Hrachovy RA; Smith KL; Swann JW
J. Neurosci., 2000


Table 1.

Summary of experiments

Experiment Control number of rats Experimental number of rats Age when infusion began1-a Duration of infusion (days) Age when infusion stopped1-a Age when results were obtained1-a
2-Deoxyglucose studies 5 5 12 14 26 26
Cresyl violet studies 5 5 12 28 40 40
In vivo EEG studies
 Recovery of neuronal activity after activity blockade 6 15 12–17 28 40–45 40–54
 Age dependence of effects of ac 6 11 10–12 28 38–40 38–52
   tivity blockade1-b 6 10 13–17 28 41–45 41–57
2 6 45–50 28 73–78 73–90
 Follow-up at 6–8 months of age 2 7 10–12 28 38–40 6–8 months
 Interictal spikes in dorsal vs ventral hippocampus 5 5 10–12 28 38–40 26–40
Long-term video monitorings 2 7 10–12 28 38–40 6–12 months
In vitro slice studies
 Recordings of remote focus in vitro 3 5 10–12 14–21 24–33 24–33
 Recordings of epileptiform bursts 2 weeks after TTX withdrawal 2 3 10–12 28 38–40 52–54
 Blockade of minibursts by:
  KYN 3 10–12 14–21 24–33 24–33
  CNQX 3 10–12 14–21 24–33 24–33
 Whole-cell recordings 3 7 10–12 14–24 24–33 24–33

  • ↵F1-a  Age in postnatal days.

  • ↵F1-b  Some animals in this study were also included in recovery of neuronal activity data.


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