Article: Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine.
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Planert H; Berger TK; Silberberg G
PLoS ONE, 2013
10.1371/journal.pone.0057054.t003
Effect of dopamine (60 µM) on membrane properties of D1 MSNs.
|
Control |
DA |
|
|
|
mean |
SD |
mean |
SD |
n |
p-value |
Baseline current (pA)
|
-5.10 |
47.03 |
-35.19 |
58.08 |
25 |
0.000
|
Baseline membrane potential for recordings (mV) |
-79.18 |
2.28 |
-79.13 |
3.13 |
25 |
0.901 |
Amplitude of first AP (mV) |
78.04 |
8.36 |
79.53 |
8.16 |
22 |
0.230 |
Duration of first AP (ms) |
1.84 |
0.46 |
1.89 |
0.58 |
22 |
0.352 |
Width of first AP (ms) |
0.77 |
0.11 |
0.77 |
0.11 |
22 |
0.659 |
Amplitude of second AP (mV) |
62.74 |
7.29 |
62.83 |
8.20 |
22 |
0.929 |
Duration of second AP (ms) |
1.90 |
0.34 |
1.86 |
0.34 |
22 |
0.132 |
Width of second AP (ms)
|
0.98 |
0.17 |
0.94 |
0.15 |
22 |
0.032
|
Amplitude change first to second AP (%) |
-19.47 |
6.03 |
-20.99 |
6.22 |
22 |
0.145 |
AP duration change (%)
|
5.41 |
11.91 |
1.29 |
12.91 |
22 |
0.015
|
AP width change (%)
|
26.44 |
11.16 |
22.96 |
9.31 |
22 |
0.010
|
Input resistance at rest (MΩ ) |
89.40 |
53.64 |
88.86 |
52.90 |
22 |
0.912 |
Input resistance [depolarized] (MΩ ) |
132.40 |
59.38 |
140.90 |
73.61 |
22 |
0.168 |
Input resistance [hyperpolarized] (MΩ ) |
52.80 |
32.36 |
56.66 |
37.63 |
23 |
0.171 |
Membrane time constant at rest (ms) |
5.20 |
2.62 |
4.95 |
2.31 |
22 |
0.334 |
Membrane time constant [depolarized] (ms) |
11.10 |
3.32 |
11.79 |
5.25 |
24 |
0.362 |
Membrane time constant [hyperpolarized] (ms)
|
1.91 |
1.20 |
2.23 |
1.85 |
24 |
0.048
|
Membrane time constant for delta pulse (ms) |
4.87 |
2.70 |
5.02 |
2.61 |
23 |
0.383 |
Threshold for APs (mV)
|
-42.36 |
2.58 |
-44.02 |
3.64 |
25 |
0.050
|
AP drop rate (mV/pA)
|
-0.02 |
0.03 |
-0.03 |
0.03 |
21 |
0.004
|
Ramp current to first spike (pA)
|
329.00 |
126.80 |
311.30 |
122.60 |
25 |
0.017
|
Minimum step current for threshold discharge (pA)
|
334.90 |
150.10 |
315.20 |
139.10 |
21 |
0.020
|
Slope of current/frequency relationship (Hz/pA) |
0.14 |
0.07 |
0.12 |
0.08 |
21 |
0.132 |
Inferred neuron-electrophysiology data values
Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
Standardized Value |
Content Source |