Article: Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine.
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Planert H; Berger TK; Silberberg G
PLoS ONE, 2013
10.1371/journal.pone.0057054.t004
Effect of dopamine (60 µM) on membrane properties of D2 MSNs.
|
Control |
DA |
|
|
|
mean |
SD |
mean |
SD |
n |
p-value |
Baseline current (pA)
|
-4.87 |
67.20 |
-25.09 |
63.24 |
19 |
0.006
|
Baseline membrane potential for recordings (mV) |
-79.30 |
2.95 |
-78.84 |
2.39 |
18 |
0.410 |
Amplitude of first AP (mV)
|
81.45 |
9.08 |
78.10 |
7.77 |
18 |
0.044
|
Duration of first AP (ms)
|
1.66 |
0.36 |
1.81 |
0.39 |
18 |
0.004
|
Width of first AP (ms)
|
0.72 |
0.09 |
0.77 |
0.10 |
18 |
0.002
|
Amplitude of second AP (mV)
|
66.89 |
10.43 |
60.26 |
9.07 |
18 |
0.000
|
Duration of second AP (ms) |
1.85 |
0.26 |
1.81 |
0.23 |
18 |
0.110 |
Width of second AP (ms) |
0.93 |
0.12 |
0.94 |
0.12 |
18 |
0.439 |
Amplitude change first to second AP (%)
|
-17.86 |
8.57 |
-22.76 |
9.26 |
18 |
0.000
|
AP duration change (%)
|
13.29 |
11.92 |
1.99 |
12.11 |
18 |
0.000
|
AP width change (%)
|
29.71 |
8.89 |
23.28 |
6.45 |
18 |
0.000
|
Input resistance at rest (MΩ )
|
86.83 |
41.30 |
93.97 |
43.04 |
17 |
0.020
|
Input resistance [depolarized] (MΩ ) |
134.70 |
46.60 |
135.90 |
41.31 |
17 |
0.770 |
Input resistance [hyperpolarized] (MΩ )
|
56.06 |
25.57 |
68.54 |
32.29 |
18 |
0.000
|
Membrane time constant at rest (ms) |
5.28 |
2.14 |
5.11 |
2.41 |
18 |
0.467 |
Membrane time constant [depolarized] (ms) |
11.19 |
2.93 |
10.97 |
3.56 |
18 |
0.689 |
Membrane time constant [hyperpolarized] (ms) |
2.58 |
2.51 |
3.68 |
4.70 |
19 |
0.261 |
Membrane time constant for delta pulse (ms) |
5.55 |
3.51 |
5.29 |
3.45 |
19 |
0.096 |
Threshold for APs (mV)
|
-45.37 |
4.25 |
-43.11 |
4.49 |
18 |
0.000
|
AP drop rate (mV/pA) |
-0.03 |
0.02 |
-0.02 |
0.02 |
18 |
0.244 |
Ramp current to first spike (pA) |
263.70 |
84.65 |
272.10 |
76.55 |
19 |
0.322 |
Minimum step current for discharge (pA) |
246.90 |
77.12 |
264.90 |
82.51 |
15 |
0.061 |
Slope of current/frequency relationship (Hz/pA)
|
0.17 |
0.09 |
0.13 |
0.09 |
15 |
0.001
|
Inferred neuron-electrophysiology data values
Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
Standardized Value |
Content Source |