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Article: Lack of depolarization-induced suppression of inhibition (DSI) in layer 2/3 interneurons that receive cannabinoid-sensitive inhibitory inputs.

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Lemtiri-Chlieh F; Levine ES
J. Neurophysiol., 2007



TABLE 1.Physiological properties of layer 2/3 pyramidal neurons and interneurons
PN (13) FS (9) RSNP (14) IS (17)
Resting potential, mV –68.8 ± 1.1 –61.9 ± 0.8 –59.0 ± 2.0 –55.0 ± 1.5
Input resistance, MΩ 272 ± 18 230 ± 28 348 ± 35 349 ± 39
Spike amplitude, mV 90.5 ± 1.2 79.4 ± 1.7 85.5 ± 1.9 70.7 ± 9.8
Spike duration, ms 1.4 ± 0.06 0.6 ± 0.04 0.9 ± 0.06 0.8 ± 0.04
AHP, mV –3.7 ± 0.6 –19.2 ± 1.3 –10.2 ± 0.9 –12 ± 0.8
Freq. accommodation, % 68 ± 2.7 11 ± 2.4 55 ± 5.8 ND
Sag potential, mV 3.0 ± 0.4 3.8 ± 0.3 11.5 ± 1.2 10.7 ± 2.1
Values are given as mean ± SE. PN, pyramidal neuron; FS, fast spiking; RSNP, regular spiking non-pyramidal; IS, irregular spiking; AHP, afterhyperpolarization; ND, not determined (due to the irregular nature of spiking in IS cells). Physiological parameters were measured as described in METHODS. Numbers of neurons are in parentheses.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 resting membrane potential (mV) -68.8 ± 1.1 (13) -68.8 (mV) Data Table
Neocortex basket cell Neocortex Layer 2-3 Fast-Spiking Interneuron resting membrane potential (mV) -61.9 ± 0.8 (9) -61.9 (mV) Data Table
Other Neocortex Layer 2-3 Regular-Spiking Non-Pyramidal Interneuron resting membrane potential (mV) -59.0 ± 2.0 (14) -59.0 (mV) Data Table
Other Neocortex Layer 2-3 Irregular-Spiking Interneuron resting membrane potential (mV) -55.0 ± 1.5 (17) -55.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 input resistance (MΩ) 272.0 ± 18.0 (13) 272.0 (MΩ) Data Table
Neocortex basket cell Neocortex Layer 2-3 Fast-Spiking Interneuron input resistance (MΩ) 230.0 ± 28.0 (9) 230.0 (MΩ) Data Table
Other Neocortex Layer 2-3 Regular-Spiking Non-Pyramidal Interneuron input resistance (MΩ) 348.0 ± 35.0 (14) 348.0 (MΩ) Data Table
Other Neocortex Layer 2-3 Irregular-Spiking Interneuron input resistance (MΩ) 349.0 ± 39.0 (17) 349.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 spike amplitude (mV) 90.5 ± 1.2 (13) 90.5 (mV) Data Table
Neocortex basket cell Neocortex Layer 2-3 Fast-Spiking Interneuron spike amplitude (mV) 79.4 ± 1.7 (9) 79.4 (mV) Data Table
Other Neocortex Layer 2-3 Regular-Spiking Non-Pyramidal Interneuron spike amplitude (mV) 85.5 ± 1.9 (14) 85.5 (mV) Data Table
Other Neocortex Layer 2-3 Irregular-Spiking Interneuron spike amplitude (mV) 70.7 ± 9.8 (17) 70.7 (mV) Data Table
Neocortex pyramidal cell layer 2-3 spike half-width (ms) 1.4 ± 0.06 (13) 1.4 (ms) Data Table
Neocortex basket cell Neocortex Layer 2-3 Fast-Spiking Interneuron spike half-width (ms) 0.6 ± 0.04 (9) 0.6 (ms) Data Table
Other Neocortex Layer 2-3 Regular-Spiking Non-Pyramidal Interneuron spike half-width (ms) 0.9 ± 0.06 (14) 0.9 (ms) Data Table
Other Neocortex Layer 2-3 Irregular-Spiking Interneuron spike half-width (ms) 0.8 ± 0.04 (17) 0.8 (ms) Data Table
Neocortex pyramidal cell layer 2-3 AHP amplitude (mV) -3.7 ± 0.6 (13) 3.7 (mV) Data Table
Neocortex basket cell Neocortex Layer 2-3 Fast-Spiking Interneuron AHP amplitude (mV) -19.2 ± 1.3 (9) 19.2 (mV) Data Table
Other Neocortex Layer 2-3 Regular-Spiking Non-Pyramidal Interneuron AHP amplitude (mV) -10.2 ± 0.9 (14) 10.2 (mV) Data Table
Other Neocortex Layer 2-3 Irregular-Spiking Interneuron AHP amplitude (mV) -12.0 ± 0.8 (17) 12.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 adaptation percent (1 – first/last ISI) 68.0 ± 2.7 (13) 68.0 (ratio) Data Table
Neocortex basket cell Neocortex Layer 2-3 Fast-Spiking Interneuron adaptation percent (1 – first/last ISI) 11.0 ± 2.4 (9) 11.0 (ratio) Data Table
Other Neocortex Layer 2-3 Regular-Spiking Non-Pyramidal Interneuron adaptation percent (1 – first/last ISI) 55.0 ± 5.8 (14) 55.0 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 sag amplitude (mV) 3.0 ± 0.4 (13) 3.0 (mV) Data Table
Neocortex basket cell Neocortex Layer 2-3 Fast-Spiking Interneuron sag amplitude (mV) 3.8 ± 0.3 (9) 3.8 (mV) Data Table
Other Neocortex Layer 2-3 Regular-Spiking Non-Pyramidal Interneuron sag amplitude (mV) 11.5 ± 1.2 (14) 11.5 (mV) Data Table
Other Neocortex Layer 2-3 Irregular-Spiking Interneuron sag amplitude (mV) 10.7 ± 2.1 (17) 10.7 (mV) Data Table