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Article: Alpha5GABAA receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons.

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Bonin RP; Martin LJ; MacDonald JF; Orser BA
J. Neurophysiol., 2007



TABLE 2.Properties of spontaneous IPSCs recorded in CA1 pyramidal neurons in hippocampal slices


WT (5)

α5–/– (5)

ACSF 20 µM L6 ACSF 20 µM L6

Peak amplitude, pA 48.4 ± 3.1 45.6 ± 4.2 52.6 ± 4.2 49.6 ± 4.2
Rise time, ms 1.4 ± 0.2 1.5 ± 0.2 1.4 ± 0.2 1.6 ± 0.6
Weighted decay tau, ms 9.4 ± 1.4 8.8 ± 1.4 9.0 ± 1.3 9.0 ± 1.2
Frequency, Hz 2.9 ± 1.2 2.8 ± 0.5 2.7 ± 1.2 2.9 ± 0.6

Values are means ± SE. Parentheses enclose n values. IPSC, inhibitory post synaptic current, ACSF, artificial cerebrospinal fluid; L6, L-655, 708.

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