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Article: Altered firing rates and patterns in interneurons in experimental cortical dysplasia.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Zhou FW; Roper SN
Cereb. Cortex, 2011


Table 1

Intrinsic membrane properties of interneurons in control and dysplastic cortex

SST-ir cells PV-ir cells CR-ir cells
Con (57) CD (38) Con (121) CD (60) Con (47) CD (33)
Rinput, MΩ 199.6 ± 14.5 209.2 ± 16.1 167.5 ± 13.5 174.3 ± 14.9 357.9 ± 21.4 346.2 ± 22.9
Time constant, ms 16.3 ± 1.4 16.8 ± 1.5 14.7 ± 1.2 15.2 ± 1.1 22.6 ± 1.9 20.2 ± 1.7
Capacitance, pF 79.5 ± 7.1 81.4 ± 7.6 90.2 ± 8.4 88.5 ± 8.8 61.6 ± 5.8 58.5 ± 5.9
AP threshold, mV -45.4 ± 1.3 -44.8 ± 1.5 -44.7 ± 1.1 -45.7 ± 1.2 -47.8 ± 1.4 -47.9 ± 1.5
AP amplitude, mV 66.2 ± 1.7 67.4 ± 1.9 64.5 ± 1.2 66.1 ± 1.3 40.5 ± 1.4 42.7 ± 1.6
AP half-width, ms 0.61 ± 0.06 0.59 ± 0.07 0.43 ± 0.03 0.46 ± 0.05 0.83 ± 0.07 0.85 ± 0.00
fAHP, mV 12.4 ± 0.8 12.2 ± 0.9 21.5 ± 1.0 20.4 ± 1.2 - -
AP adaptation 2.31 ± 0.19 2.12 ± 0.17 1.02 ± 0.08 1.04 ± 0.07 8.92 ± 0.86 8.14 ± 0.83
f - I slope, Hz/nA 159.2 ± 10.9 163.8 ± 11.7 365.5 ± 19.2 383.1 ± 21.6 - -
  • AP, action potential; Con, control; CD, cortical dysplasia; fAHP, fast afterhyperpolarization; f - I slope, slope of the relationship between injected current intensity and firing rate; Rinput, input resistance.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex Martinotti cell Somatosensory cortex layer 4 fusiform GABAergic somatostatin-immunoreactive interneuron input resistance (MΩ) 199.6 ± 14.5 (57) 199.6 (MΩ) Data Table
Neocortex basket cell Somatosensory cortex layer 4 GABAergic parvalbumin-immunoreactive interneuron input resistance (MΩ) 167.5 ± 13.5 (121) 167.5 (MΩ) Data Table
Neocortex uncharacterized cell Somatosensory cortex GABAergic layer 4 calretinin-immunoreactive interneuron input resistance (MΩ) 357.9 ± 21.4 (47) 357.9 (MΩ) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 4 fusiform GABAergic somatostatin-immunoreactive interneuron membrane time constant (ms) 16.3 ± 1.4 (57) 16.3 (ms) Data Table
Neocortex basket cell Somatosensory cortex layer 4 GABAergic parvalbumin-immunoreactive interneuron membrane time constant (ms) 14.7 ± 1.2 (121) 14.7 (ms) Data Table
Neocortex uncharacterized cell Somatosensory cortex GABAergic layer 4 calretinin-immunoreactive interneuron membrane time constant (ms) 22.6 ± 1.9 (47) 22.6 (ms) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 4 fusiform GABAergic somatostatin-immunoreactive interneuron cell capacitance (pF) 79.5 ± 7.1 (57) 79.5 (pF) Data Table
Neocortex basket cell Somatosensory cortex layer 4 GABAergic parvalbumin-immunoreactive interneuron cell capacitance (pF) 90.2 ± 8.4 (121) 90.2 (pF) Data Table
Neocortex uncharacterized cell Somatosensory cortex GABAergic layer 4 calretinin-immunoreactive interneuron cell capacitance (pF) 61.6 ± 5.8 (47) 61.6 (pF) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 4 fusiform GABAergic somatostatin-immunoreactive interneuron spike threshold (mV) -45.4 ± 1.3 (57) -45.4 (mV) Data Table
Neocortex basket cell Somatosensory cortex layer 4 GABAergic parvalbumin-immunoreactive interneuron spike threshold (mV) -44.7 ± 1.1 (121) -44.7 (mV) Data Table
Neocortex uncharacterized cell Somatosensory cortex GABAergic layer 4 calretinin-immunoreactive interneuron spike threshold (mV) -47.8 ± 1.4 (47) -47.8 (mV) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 4 fusiform GABAergic somatostatin-immunoreactive interneuron spike amplitude (mV) 66.2 ± 1.7 (57) 66.2 (mV) Data Table
Neocortex basket cell Somatosensory cortex layer 4 GABAergic parvalbumin-immunoreactive interneuron spike amplitude (mV) 64.5 ± 1.2 (121) 64.5 (mV) Data Table
Neocortex uncharacterized cell Somatosensory cortex GABAergic layer 4 calretinin-immunoreactive interneuron spike amplitude (mV) 40.5 ± 1.4 (47) 40.5 (mV) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 4 fusiform GABAergic somatostatin-immunoreactive interneuron spike half-width (ms) 0.61 ± 0.06 (57) 0.61 (ms) Data Table
Neocortex basket cell Somatosensory cortex layer 4 GABAergic parvalbumin-immunoreactive interneuron spike half-width (ms) 0.43 ± 0.03 (121) 0.43 (ms) Data Table
Neocortex uncharacterized cell Somatosensory cortex GABAergic layer 4 calretinin-immunoreactive interneuron spike half-width (ms) 0.83 ± 0.07 (47) 0.83 (ms) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 4 fusiform GABAergic somatostatin-immunoreactive interneuron fast AHP amplitude (mV) 12.4 ± 0.8 (57) 12.4 (mV) Data Table
Neocortex basket cell Somatosensory cortex layer 4 GABAergic parvalbumin-immunoreactive interneuron fast AHP amplitude (mV) 21.5 ± 1.0 (121) 21.5 (mV) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 4 fusiform GABAergic somatostatin-immunoreactive interneuron adaptation ratio (last/first ISI) 2.31 ± 0.19 (57) 2.31 (ratio) Data Table
Neocortex basket cell Somatosensory cortex layer 4 GABAergic parvalbumin-immunoreactive interneuron adaptation ratio (last/first ISI) 1.02 ± 0.08 (121) 1.02 (ratio) Data Table
Neocortex uncharacterized cell Somatosensory cortex GABAergic layer 4 calretinin-immunoreactive interneuron adaptation ratio (last/first ISI) 8.92 ± 0.86 (47) 8.92 (ratio) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 4 fusiform GABAergic somatostatin-immunoreactive interneuron FI slope (Hz/nA) 159.2 ± 10.9 (57) 159.2 (Hz/nA) Data Table
Neocortex basket cell Somatosensory cortex layer 4 GABAergic parvalbumin-immunoreactive interneuron FI slope (Hz/nA) 365.5 ± 19.2 (121) 365.5 (Hz/nA) Data Table