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Article: Two calretinin-positive GABAergic cell types in layer 2/3 of the mouse neocortex provide different forms of inhibition.

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Caputi A; Rozov A; Blatow M; Monyer H
Cereb. Cortex, 2009


Table 2

Electrical parameters of MCR and BCR cells compared with MB and FS cells

Cell type Input resistance (MOhm) Vm (mV) Threshold potential (mV) AP half width (ms) AP amplitude (mV) AP attenuation (% of amplitude) Interspike interval (ms) AP accommodation (% of IS interval) Main firing frequency (Hz) Burst frequency (Hz) AHP duration (ms) Membrane time constant (ms)
MCR, n = 13 558 ± 170 -64 ± 3 -41 ± 3 1.4 ± 0.2 74 ± 5** 82 ± 6 23 ± 6 218 ± 6 31 ± 8 - - 45.8 ± 14.3
BCR, n = 10 675 ± 163 -66 ± 2 -41 ± 3 1.5 ± 0.2 67 ± 2** - - - 22 ± 3 82 ± 22 66 ± 17 43.2 ± 8.9
MB, n = 11 111 ± 39 -60 ± 3** -43 ± 3 0.9 ± 0.3 81 ± 9 - - - 13 ± 2** 71 ± 20 166 ± 37 22.7 ± 7.2
FS, n = 11 82 ± 31 -73 ± 3** -37 ± 3 0.7 ± 0.1 77 ± 6 - - - 38 ± 9** - - 10.4 ± 2.4
  • Note: All measurements were performed at room temperature. Input resistances were derived from Ohm's law dividing the maximal averaged voltage deflection to 40 pA hyperpolarizing current pulses by the applied amplitude of the current pulse. Firing properties were analyzed upon 500 pA current injection for 1 s for all cell types. AP half widths and amplitude were measured on the first AP in the train upon depolarizing current injection at threshold level. AP attenuation and accommodation were measured as a change of initial amplitude and interspike interval at the beginning and at the end of the AP train. AHP duration was measured as the time from the end of the initial burst to the regular spiking part of the firing pattern. Vm = resting potential; IS = interspike; AHP = after-hyperpolarization. Attenuation and accommodation were expressed as percentage of initial amplitude and interspike interval to the vales measured at the end of AP train.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex uncharacterized cell neocortex layer 1-2 large oval or round multipolar bursting parvalbumin-positive GABAergic interneuron spike threshold (mV) -43.0 ± 3.0 (11) -43.0 (mV) Data Table
Neocortex uncharacterized cell neocortex layer 1-2 large oval or round multipolar bursting parvalbumin-positive GABAergic interneuron spike half-width (ms) 0.9 ± 0.3 (11) 0.9 (ms) Data Table
Neocortex uncharacterized cell neocortex layer 1-2 large oval or round multipolar bursting parvalbumin-positive GABAergic interneuron spike amplitude (mV) 81.0 ± 9.0 (11) 81.0 (mV) Data Table
Neocortex uncharacterized cell neocortex layer 1-2 large oval or round multipolar bursting parvalbumin-positive GABAergic interneuron firing frequency (Hz) 13.0 ± 2.0 (11) 13.0 (Hz) Data Table
Neocortex uncharacterized cell neocortex layer 1-2 large oval or round multipolar bursting parvalbumin-positive GABAergic interneuron AHP duration (ms) 166.0 ± 37.0 (11) 166.0 (ms) Data Table
Neocortex uncharacterized cell neocortex layer 1-2 large oval or round multipolar bursting parvalbumin-positive GABAergic interneuron membrane time constant (ms) 22.7 ± 7.2 (11) 22.7 (ms) Data Table
Other neocortex layer 2-3 large oval or round fast spiking parvalbumin-positive GABAergic interneuron input resistance 82.0 ± 31.0 (11) 82.0 (MΩ) Data Table
Other neocortex layer 2-3 large oval or round fast spiking parvalbumin-positive GABAergic interneuron resting membrane potential (mV) -73.0 ± 3.0 (11) -73.0 (mV) Data Table
Other neocortex layer 2-3 large oval or round fast spiking parvalbumin-positive GABAergic interneuron spike threshold (mV) -37.0 ± 3.0 (11) -37.0 (mV) Data Table
Other neocortex layer 2-3 large oval or round fast spiking parvalbumin-positive GABAergic interneuron spike half-width (ms) 0.7 ± 0.1 (11) 0.7 (ms) Data Table
Other neocortex layer 2-3 large oval or round fast spiking parvalbumin-positive GABAergic interneuron spike amplitude (mV) 77.0 ± 6.0 (11) 77.0 (mV) Data Table
Other neocortex layer 2-3 large oval or round fast spiking parvalbumin-positive GABAergic interneuron firing frequency (Hz) 38.0 ± 9.0 (11) 38.0 (Hz) Data Table
Other neocortex layer 2-3 large oval or round fast spiking parvalbumin-positive GABAergic interneuron membrane time constant (ms) 10.4 ± 2.4 (11) 10.4 (ms) Data Table
Neocortex uncharacterized cell neocortex layer 2-3 multipolar round bodied calretinin-expressing GABAergic interneuron input resistance 558.0 ± 170.0 (13) 558.0 (MΩ) Data Table
Neocortex uncharacterized cell neocortex layer 2-3 multipolar round bodied calretinin-expressing GABAergic interneuron resting membrane potential (mV) -64.0 ± 3.0 (13) -64.0 (mV) Data Table
Neocortex uncharacterized cell neocortex layer 2-3 multipolar round bodied calretinin-expressing GABAergic interneuron spike threshold (mV) -41.0 ± 3.0 (13) -41.0 (mV) Data Table
Neocortex uncharacterized cell neocortex layer 2-3 multipolar round bodied calretinin-expressing GABAergic interneuron spike half-width (ms) 1.4 ± 0.2 (13) 1.4 (ms) Data Table
Neocortex uncharacterized cell neocortex layer 2-3 multipolar round bodied calretinin-expressing GABAergic interneuron spike amplitude (mV) 74.0 ± 5.0 (13) 74.0 (mV) Data Table
Neocortex uncharacterized cell neocortex layer 2-3 multipolar round bodied calretinin-expressing GABAergic interneuron adaptation ratio 218.0 ± 6.0 (13) -- Data Table
Neocortex uncharacterized cell neocortex layer 2-3 multipolar round bodied calretinin-expressing GABAergic interneuron firing frequency (Hz) 31.0 ± 8.0 (13) 31.0 (Hz) Data Table
Neocortex uncharacterized cell neocortex layer 2-3 multipolar round bodied calretinin-expressing GABAergic interneuron membrane time constant (ms) 45.8 ± 14.3 (13) 45.8 (ms) Data Table
Neocortex bipolar cell neocortex layer 2-3 bipolar elongated soma calretinin-expressing GABAergic interneuron input resistance 675.0 ± 163.0 (10) 675.0 (MΩ) Data Table
Neocortex bipolar cell neocortex layer 2-3 bipolar elongated soma calretinin-expressing GABAergic interneuron resting membrane potential (mV) -66.0 ± 2.0 (10) -66.0 (mV) Data Table
Neocortex bipolar cell neocortex layer 2-3 bipolar elongated soma calretinin-expressing GABAergic interneuron spike threshold (mV) -41.0 ± 3.0 (10) -41.0 (mV) Data Table
Neocortex bipolar cell neocortex layer 2-3 bipolar elongated soma calretinin-expressing GABAergic interneuron spike half-width (ms) 1.5 ± 0.2 (10) 1.5 (ms) Data Table
Neocortex bipolar cell neocortex layer 2-3 bipolar elongated soma calretinin-expressing GABAergic interneuron spike amplitude (mV) 67.0 ± 2.0 (10) 67.0 (mV) Data Table
Neocortex bipolar cell neocortex layer 2-3 bipolar elongated soma calretinin-expressing GABAergic interneuron firing frequency (Hz) 22.0 ± 3.0 (10) 22.0 (Hz) Data Table
Neocortex bipolar cell neocortex layer 2-3 bipolar elongated soma calretinin-expressing GABAergic interneuron AHP duration (ms) 66.0 ± 17.0 (10) 66.0 (ms) Data Table
Neocortex bipolar cell neocortex layer 2-3 bipolar elongated soma calretinin-expressing GABAergic interneuron membrane time constant (ms) 43.2 ± 8.9 (10) 43.2 (ms) Data Table
Neocortex uncharacterized cell neocortex layer 1-2 large oval or round multipolar bursting parvalbumin-positive GABAergic interneuron input resistance 111.0 ± 39.0 (11) 111.0 (MΩ) Data Table
Neocortex uncharacterized cell neocortex layer 1-2 large oval or round multipolar bursting parvalbumin-positive GABAergic interneuron resting membrane potential (mV) -60.0 ± 3.0 (11) -60.0 (mV) Data Table