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Article: Myelination defects and neuronal hyperexcitability in the neocortex of connexin 32-deficient mice.

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Sutor B; Schmolke C; Teubner B; Schirmer C; Willecke K
Cereb. Cortex, 2000


Table 1

Comparison of morphological parameters determined in wild-type and Cx32-deficient mice

Wild-type mice Cx32-deficient mice Difference (in %)
Values given as mean ± SD; *significantly different at the 5% level; NS, not significant.
aWithout cerebellum and brain stem (cf. Materials and methods).
bShort diameter of axon profiles (cf. Materials and methods).
Body weight (in g) (n = 4 mice) 29.71 ± 3.30 24.55 ± 2.31 17.4* (P = 0.043)
Brain weighta (in g) (n = 4 mice) 0.36 ± 0.01 0.33 ± 0.01 8.3* (P = 0.0005)
Thickness of neocortex (in μm, n = 30 sections, 3 mice) 1250.87 ± 68.91 1104.04 ± 24.07 11.7 (NS)
Number of axons per μm2 (n = 3 mice) 0.55 ± 0.07 0.46 ± 0.06 16.4 (NS)
Diameterb of axons (in μm, n = 100 axons, 3 mice) 0.49 ± 0.01 0.46 ± 0.03 4.1 (NS)
Thickness of myelin sheath (in μm, n = 100 axons, 3 mice) 0.15 ± 0.01 0.13 ± 0.01 13.3* (P = 0.023)
Volume fraction of myelin (in %, n = 3 mice) 17.43 ± 1.12 14.13 ± 1.36 18.9* (P = 0.031)

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