TABLE 2.Voltage-dependent properties of somatic currents
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YFP-16 | GIN | |
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Itotal (TTX-insensitive) | ||
v1/2, mV | –18.2 ± 3.8 | –17.4 ± 6.0 |
k, mV | 7.1 ± 1.9 | 8.1 ± 2.8 |
IKCa (Cd-sensitive) | ||
v1/2, mV | –27.0 ± 4.9 | –22.1 ± 5.3** |
k, mV | 5.3 ± 2.8 | 8.2 ± 2.5*** |
I1TEA (1 mM TEA-sensitive) | ||
v1/2, mV | –9.3 ± 2.4 | –7.6 ± 3.2 |
k, mV | 7.4 ± 1.3 | 8.2 ± 1.8 |
I10TEA (10 mM TEA-sensitive) | ||
v1/2, mV | –4.3 ± 5.0 | –2.8 ± 4.3 |
k, mV | 8.6 ± 1.5 | 9.1 ± 1.6 |
IA (10 mM TEA-insensitive) | ||
v1/2, mV | –12.5 ± 3.8 | –13.3 ± 4.2 |
k, mV | 10.0 ± 1.4 | 10.3 ± 2.4 |
Currents recorded from YFP-16 (n = 20) and GIN (n = 19) neurons, measured by fitting normalized conductance graphs with a Boltzmann fit: gmax/[1 + exp(V1/2–V)/k), where gmax is the normalized maximum conductance, V1/2 is the voltage at which half of the channels are open or closed, V is the voltage at which conductance was calculated, corrected for Rseries errors, and k is the slope, a measure of the voltage-dependence of the channel. Averages and standard deviations of V1/2 and k are shown for each current in YFP-16 and GIN neurons. Significant differences are indicated,
** P < 0.01,
*** P < 0.0005.