Basal electrical properties of PCs in wild-type and mutant mice
Properties
Wild-type
Mutant
Resting potential, mV
-63±1 (10)
-61±2 (8)
Action potential
Frequency, Hz
28±2 (31)
26±2 (32)
Amplitude, mV
62±2 (10)
60±2 (8)
Half-height width, ms
0.8±0.1 (10)
0.8±0.1 (8)
Threshold, mV
-41±0.6 (10)
-41±1.3 (8)
Input resistance, MΩ
294±29 (12)
313±45 (10)
mEPSC
Amplitude, pA
11.3±0.4 (20)
12.8±0.5 (20)
Frequency, Hz
4.1±0.7 (20)
3.2±0.3 (20)
Half-height width, ms
12.9±0.8 (10)
12.8±0.7 (10)
10-90% rise time, ms
2.6±0.2 (10)
2.7±0.2 (10)
mGluR response
Amplitude, pA
123±9 (6)
113±9 (6)
Half-height width, ms
737±121 (6)
989±206 (6)
10-90% rise time, ms
171±14 (6)
218±29 (6)
Ca2+ current at 0 mV, nA
2.0±0.3 (6)
1.8±0.2 (6)
Data are expressed as mean±SEM. Numbers in parentheses indicate the number of neurons. mGluR1 mediated synaptic response was induced by 10 pulses. There were no significant differences between wild-type and mutant PCs in basal electrical properties (Student's t test, p>0.1 in all cases) except for the amplitude of mEPSC (p = 0.02).
