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Article: Kv4.2 mediates histamine modulation of preoptic neuron activity and body temperature.

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Sethi J; Sanchez-Alavez M; Tabarean IV
PLoS ONE, 2011


10.1371/journal.pone.0029134.t001 Properties of preoptic GABAergic w-t and Kv4.2-/- neurons.
Parameter w-t n Kv4.2-/- n
r.m.p. (mV) -52.3±4.4 14 -50.6±5.1* 15
Rinput (MΩ) 407±62 14 427±53 15
S. f. r. (Hz) 10.2±3.7 14 9.4±3.5 15
AP amplitude (mV) 77.2±4.4 14 78.3±5.7 15
AP threshold (mV) -43±3 14 -44±4 15
AP halfwidth (mV) 0.8±0.1 14 0.9±0.1 15
AHP amplitude (mV) -17.8±3.1 14 -19.2±3.2 15
AHP time to peak (ms) 5.5±3.4 14 4.9±3.9 15
AHP decay (mV/ms) 0.23±0.22 14 0.25±0.2 15
Peak IA density at 0 mV (pA/pF) 58.6±19.5 14 41.8±12.9* 15
ISS density at 0 mV (pA/pF) 45.4±19.5 14 82.3±27.5** 15

Values are presented as mean ± S.D., * and ** indicate P<0.05 and P<0.01, respectively (unpaired t-tests), (n)-number of cells.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Hypothalamus median preoptic nucleus GABAergic pacemaker-firing cell input resistance (MΩ) 407.0 ± 62.0 (14) 407.0 (MΩ) Data Table
Other Hypothalamus median preoptic nucleus GABAergic pacemaker-firing cell spontaneous firing rate (Hz) 10.2 ± 3.7 (14) 10.2 (Hz) Data Table
Other Hypothalamus median preoptic nucleus GABAergic pacemaker-firing cell spike amplitude (mV) 77.2 ± 4.4 (14) 77.2 (mV) Data Table
Other Hypothalamus median preoptic nucleus GABAergic pacemaker-firing cell spike threshold (mV) -43.0 ± 3.0 (14) -43.0 (mV) Data Table
Other Hypothalamus median preoptic nucleus GABAergic pacemaker-firing cell spike half-width (mV) 0.8 ± 0.1 (14) -- Data Table
Other Hypothalamus median preoptic nucleus GABAergic pacemaker-firing cell AHP amplitude (mV) -17.8 ± 3.1 (14) 17.8 (mV) Data Table
Other Hypothalamus median preoptic nucleus GABAergic pacemaker-firing cell AHP duration (ms) 5.5 ± 3.4 (14) 5.5 (ms) Data Table
Other Hypothalamus median preoptic nucleus GABAergic pacemaker-firing cell resting membrane potential (mV) -52.3 ± 4.4 (14) -52.3 (mV) Data Table