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Article: Potentially epileptogenic dysfunction of cortical NMDA- and GABA-mediated neurotransmission in Otx1-/- mice.

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Sancini G; Franceschetti S; Lavazza T; Panzica F; Cipelletti B; Frassoni C; Spreafico R; Acampora D; Avanzini G
Eur. J. Neurosci., 2001


Table 1. Passive properties and action potential (AP) parameters in adapting regular spiking (RSAD) and intrinsically bursting (IB) neurons recorded in Otx1-/- and wild-type mice
Otx1-/-Wild-type
nRSADnIBnRSADnIB
Vrest (mV)19-64.5 ± 0.79-65.0 ± 0.818-63.8 ± 0.710-65.5 ± 1.1
Rin1 (MΩ)2196.5 ± 7.1856.1 ± 6.51687.2 ± 9.6956.3 ± 6.6
Rin2 (MΩ)2193.2 ± 6.8847.6 ± 4.71686.7 ± 7.7947.8 ± 5.7
τm (ms)2111.7 ± 0.687.8 ± 0.7169.5 ± 0.6298.1 ± 0.6
AP threshold (mV)19-49.2 ± 0.88-52.2 ± 1.613-48.6 ± 1.19-50.9 ± 1.8
AP width (ms)191.69 ± 0.681.37 ± 0.06121.78 ± 0.0691.37 ± 0.06
AP slope (V/s)19210 ± 8.08220 ± 7.712198.7 ± 13.29223.1 ± 12.1
AP amplitude (mV)1993.2 ± 3.2689.5 ± 3.41289.8 ± 3.6990.4 ± 2.9

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron input resistance (MΩ) 87.2 ± 9.6 (16) 87.2 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron input resistance (MΩ) 56.3 ± 6.6 (9) 56.3 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron membrane time constant (ms) 9.5 ± 0.62 (16) 9.5 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron membrane time constant (ms) 8.1 ± 0.6 (9) 8.1 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron spike threshold (mV) -48.6 ± 1.1 (16) -48.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron spike threshold (mV) -50.9 ± 1.8 (9) -50.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron spike width (ms) 1.78 ± 0.06 (16) 1.78 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron spike width (ms) 1.37 ± 0.06 (9) 1.37 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron spike max rise slope (V/s) 198.7 ± 13.2 (16) 198.7 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron spike max rise slope (V/s) 223.1 ± 12.1 (9) 223.1 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron resting membrane potential (mV) -63.8 ± 0.7 (16) -63.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Regular Spiking Pyramidal Neuron spike amplitude (mV) 89.8 ± 3.6 (16) 89.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron spike amplitude (mV) 90.4 ± 2.9 (9) 90.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Sensorimotor Neocortex Layer 5 Intrinsically Bursting Pyramidal Neuron resting membrane potential (mV) -65.5 ± 1.1 (9) -65.5 (mV) Data Table