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Article: Transgenic mice expressing a fluorescent in vivo label in a distinct subpopulation of neocortical layer 5 pyramidal cells.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Akemann W; Zhong YM; Ichinohe N; Rockland KS; Knöpfel T
J. Comp. Neurol., 2004


Table 1. Morphometric and Physiological Properties of EYFP(+) and EYFP(-) Layer 5 Pyramidal Neurons1
EYFP(+) cellsEYFP(-) cells
Morphological parameters
Oblique dendrites (n)3.6 ± 0.4*** (n = 25)10.9 ± 1.4 (n = 12)
Tuft branches (n)6.1 ± 0.5 (n = 27)6.6 ± 1.2 (n = 10)
Apical tuft, width (μm)144 ± 15162 ± 35 (n = 9)
Basal dendrite, length (μm)254 ± 17* (n = 23)182 ± 20
Apical dendrite, diameter (μm)2.1 ± 0.2*** (n = 21)3.0 ± 0.2 (n = 10)
Soma, long axis (μm)15.6 ± 0.5* (n = 30)17.6 ± 0.7 (n = 19)
Soma, transverse axis (μm)10.2 ± 0.2***13.6 ± 0.4
Physiological parameters at 23-25° C
Capacitance (pF)56 ± 4*** (n = 33)162 ± 12 (n = 25)
Input resistance (MΩ)344 ± 18***162 ± 19
Time constant (msec)19.2 ± 1.322.5 ± 1.5
Action potential, halfwidth (msec)1.38 ± 0.04**1.21 ± 0.04
Depolarization slope2 (mV/msec)279 ± 11310 ± 15
Repolarization slope2 (mV/msec)-64 ± 3-65 ± 3
Ih-induced voltage sag3 (%)14 ± 2* (n = 27)20 ± 2 (n = 25)
Physiological parameters at 34°C
Capacitance (pF)63 ± 4*** (n = 9)173 ± 17 (n = 17)
Input resistance (MΩ)316 ± 32***79 ± 8
Time constant (ms)21 ± 2**12 ± 1
Action potential, halfwidth (msec)0.83 ± 0.060.75 ± 0.04
Depolarization slope2 (mV/msec)426 ± 21441 ± 29
Repolarization slope2 (mV/msec)-95 ± 7-99 ± 6
Ih-induced voltage sag3 (%)14 ± 317 ± 2

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 Kv3.1 expressing pyramidal cell cell capacitance (pF) 63.0 ± 4.0 (9) 63.0 (pF) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 Kv3.1 non-expressing pyramidal cell cell capacitance (pF) 173.0 ± 17.0 (17) 173.0 (pF) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 Kv3.1 expressing pyramidal cell input resistance (MΩ) 316.0 ± 32.0 316.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 Kv3.1 non-expressing pyramidal cell input resistance (MΩ) 79.0 ± 8.0 79.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 Kv3.1 expressing pyramidal cell membrane time constant (ms) 21.0 ± 2.0 21.0 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 Kv3.1 non-expressing pyramidal cell membrane time constant (ms) 12.0 ± 1.0 12.0 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 Kv3.1 expressing pyramidal cell spike half-width (msec) 0.83 ± 0.06 0.83 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 Kv3.1 non-expressing pyramidal cell spike half-width (msec) 0.75 ± 0.04 0.75 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 Kv3.1 expressing pyramidal cell spike max rise slope (mV/msec) 426.0 ± 21.0 426.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 Kv3.1 non-expressing pyramidal cell spike max rise slope (mV/msec) 441.0 ± 29.0 441.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 Kv3.1 expressing pyramidal cell spike max decay slope (mV/msec) -95.0 ± 7.0 95.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Neocortex layer 5 Kv3.1 non-expressing pyramidal cell spike max decay slope (mV/msec) -99.0 ± 6.0 99.0 (mV/ms) Data Table