Article: Nicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus.
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Xiao C; Miwa JM; Henderson BJ; Wang Y; Deshpande P; McKinney SL; Lester HA
J. Neurosci., 2015
Table 3.
Chronic nicotine effects on nAChRs in STN neurons
|
Treatment |
n |
None, % |
α4β2, % |
α7, % |
χ2 |
p |
| Wild-type |
7 d |
Vehicle |
41 |
41 |
22 |
37 |
6.46 |
0.03 |
| Nicotine |
36 |
16 |
42 |
42 |
|
|
| 14 d |
Vehicle |
35 |
38 |
18 |
44 |
11.5 |
0.003 |
| Nicotine |
57 |
17 |
51 |
32 |
|
|
| 3 weeks withdrawal |
Vehicle |
50 |
38 |
20 |
42 |
5.97 |
0.05 |
| Nicotine |
23 |
26 |
48 |
26 |
|
|
| α4 KO |
Naive |
|
25 |
56 |
- |
44 |
|
|
Inferred neuron-electrophysiology data values
| Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
Standardized Value |
Content Source |
