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Article: Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease.

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Hall AM; Throesch BT; Buckingham SC; Markwardt SJ; Peng Y; Wang Q; Hoffman DA; Roberson ED
J. Neurosci., 2015


Table 1.

Somatic firing properties of CA1 pyramidal neurons in hAPPJ20 micea

NTG (n = 31 cells) hAPPJ20 (n = 23 cells)
AP onset (ms) 18.57 ± 1.45 18.52 ± 1.46
AP threshold (mV) -46.10 ± 0.65 -46.13 ± 0.46
AP amplitude (mV) 96.78 ± 1.00 96.37 ± 1.04
AP half-width (ms) 0.76 ± 0.12 0.73 ± 0.13
AHP amplitude (mV) 6.85 ± 0.47 7.48 ± 0.45
AP number 34.84 ± 1.38 32.99 ± 1.15
  • aSomatic firing properties were calculated from the first AP elicited upon a 1 S, 200 pA current injection in whole-cell current-clamp recordings from the soma of NTG and hAPPJ20 mice. No significant differences were found between genotypes. Neurons were held at -65 mV, and series resistance was monitored between each trial. Three trials were recorded per cell, and the results were averaged by cell. Threshold was defined as the point when the slope reached 10 mV/ms. AP onset was the time between initiating the current injection and threshold. Maximum AHP and peak AP amplitude were measured relative to threshold, and AP half-width was measured at 50% maximum amplitude. AP number is the total number of APs elicited by the current injection.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell spike half-width (ms) 0.76 ± 0.12 (31) 0.76 (ms) Data Table
Hippocampus CA1 pyramidal cell AHP amplitude (mV) 6.85 ± 0.47 (31) 6.85 (mV) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -46.1 ± 0.65 (31) -46.1 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 96.78 ± 1.0 (31) 96.78 (mV) Data Table