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Article: Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics.

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Lioudyno MI; Birch AM; Tanaka BS; Sokolov Y; Goldin AL; Chandy KG; Hall JE; Alkire MT
J. Neurosci., 2013


Table 1.

The effect of 0.2 mm sevoflurane on tonic action potential firing properties

Resting potential (mV) AP threshold (mV) Peak amplitude (mV) Half-width (ms) ΔVt Input resistance (MΩ) n
Control -59.4 ± 0.6 -35.8 ± 0.6 23.6 ± 3.1 0.55 ± 0.01 0.51 ± 0.1 211 ± 11 9
0.2 mm sevoflurane -57.5 ± 1.7 -35.3 ± 0.9 22.8 ± 2.9 0.58 ± 0.02 0.43 ± 0.1* 229 ± 10* 9
  • The series of action potentials was induced by injection of 40 pA current in neurons with membrane potential of -60 mV prior to the application of depolarizing current pulses. The data are presented as mean ± SEM.

  • *p < 0.05 (vs control, paired t test).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Central medial thalamic nucleus neurons resting membrane potential (mV) -59.4 ± 0.6 (9) -59.4 (mV) Data Table
Other Central medial thalamic nucleus neurons spike threshold (mV) -35.8 ± 0.6 (9) -35.8 (mV) Data Table
Other Central medial thalamic nucleus neurons spike peak (mV) 23.6 ± 3.1 (9) 23.6 (mV) Data Table
Other Central medial thalamic nucleus neurons spike half-width (ms) 0.55 ± 0.01 (9) 0.55 (ms) Data Table
Other Central medial thalamic nucleus neurons input resistance (MΩ) 211.0 ± 11.0 (9) 211.0 (MΩ) Data Table