Pyramidal cell | FS IN | O-LM cell | |||||||
---|---|---|---|---|---|---|---|---|---|
n | p | n | p | n | p | ||||
10 μm DHPG | 0.346 ± 0.071 | 5 | <0.001 | 1.019 ± 0.049 | 9 | 0.165 | 0.891 ± 0.026 | 5 | 0.315 |
50 μm DHPG | 0.483 ± 0.049 | 11 | <0.001 | 0.258 ± 0.064 | 11 | <0.001 | 0.333 ± 0.029 | 5 | 0.002 |
+MPEP | 1.006 ± 0.177 | 7 | 0.011 | 1.064 ± 0.075 | 7 | <0.001 | 0.989 ± 0.038 | 8 | <0.001 |
+LY 367385 | 0.738 ± 0.070 | 3 | 0.007 | 0.676 ± 0.069 | 3 | 0.013 | 1.281 ± 0.265 | 6 | 0.021 |
+BAPTA, 0 mm Ca2+ | 0.870 ± 0.026 | 5 | <0.001 | 1.027 ± 0.066 | 3 | 0.001 | 0.937 ± 0.039 | 3 | 0.001 |
+BAPTA, 2 mm Ca2+ | 1.021 ± 0.028 | 7 | <0.001 | 1.022 ± 0.073 | 5 | <0.001 | 0.99 ± 0.036 | 4 | <0.001 |
+THL | 1.079 ± 0.105 | 5 | 0.003 | 0.962 ± 0.073 | 7 | 0.002 | 1.011 ± 0.044 | 6 | <0.001 |
+AM 251 | 0.519 ± 0.051 | 4 | 0.143 | 0.930 ± 0.073 | 5 | <0.001 | 1.309 ± 0.380 | 6 | 0.072 |
CB1 KO | 1.038 ± 0.043 | 8 | <0.001 | 0.985 ± 0.035 | 8 | <0.001 | 1.099 ± 0.144 | 3 | <0.001 |
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Data are expressed as mean ± SEM. Student's paired t test was used to evaluate the significant changes upon 10 or 50 μm DHPG treatments (first two rows). In all other cases, independent-samples t test was used for statistical comparison. The p values are the results of the comparisons between the data obtained upon 50 μm DHPG application in the absence and the presence of different drugs, or in the measurements conducted in slices prepared from wild-type or CB1 knock-out mice.