Table 3.
In vitro IC50 and concentrations of various COX inhibitors and prostaglandin receptor antagonists used for inhibition in tissue
| Inhibitor/antagonist | In vitro IC50 (or Ki) | Concentrations used for inhibition in brain tissue | ||
|---|---|---|---|---|
| Preparation | Concentration | |||
| Indomethacin | COX-1: 22 nm | COX-2: 87 nm | Brain slices | 5 μm |
| (Lora et al., 1998) | (Zonta et al., 2003) | |||
| SC 560 | COX-1: 9 nm | COX-2: 6.3 μm | Brain slices | 100 nm |
| (Smith et al., 1998) | (Blanco et al., 2008) | |||
| NS 398 | COX-1: 50 μm | COX-2: 0.6 μm | Brain slices | 10 μm |
| (Lora et al., 1998) | (Slanina and Schweitzer, 2005) | |||
| AH 6809 | EP1: 1.3 μm (Ki) | EP2: 0.5 μm (Ki) | Isolated cerebrovascular arterioles | 10 μm |
| (Boie et al., 1997) | (Myren et al., 2010; Dabertrand et al., 2013) | |||
| L 161-982 | EP4: 100 nm | Brain slices | 1 μm | |
| (Machwate et al., 2001) | (Hall et al., 2014) | |||
| CAY 10441 | IP: 7 nm | Not available | ||
| (Bley et al., 2006) | ||||