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Article: Rapid dynamic changes of dendritic inhibition in the dentate gyrus by presynaptic activity patterns.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Liu YC; Cheng JK; Lien CC
J. Neurosci., 2014


Table 1.

Functional properties of IN-to-GC connectionsa

CB1R+IN→GC HICAP→GC HIPP→GC PV+BC→GC
AP half-width (ms) 1.7 ± 0.1 1.7 ± 0.1 1.9 ± 0.2 1.2 ± 0.1
CV of ISI 0.75 ± 0.20 0.80 ± 0.26 0.54 ± 0.32 0.09 ± 0.01
Rin (MΩ) 303 ± 13 343 ± 18 295 ± 48 109 ± 20
τm (ms) 42.2 ± 3.2 45.9 ± 1.6 40.8 ± 5.2 16.5 ± 2.6
Latency (ms) 3.4 ± 0.3 3.8 ± 0.3 3.7 ± 0.4 1.6 ± 0.2
20-80% rise time (ms) 1.6 ± 0.4 1.8 ± 0.3 2.5 ± 0.1 0.7 ± 0.1
uIPSC decay τ (ms) 19.9 ± 5.5 27.2 ± 5.2 40.7 ± 6.8 16.4 ± 4.4
Peak amplitude of uIPSC (pA)b 12.0 ± 4.5 1.7 ± 0.5 9.2 ± 5.8 32.5 ± 8.9
Peak amplitude of uIPSC1 (pA)c 118.0 ± 78.3 16.1 ± 3.5 14.5 ± 8.7 24.0 ± 9.0
Charge transfer per AP (pC)b 0.18 ± 0.08 0.03 ± 0.01 0.15 ± 0.06 0.51 ± 0.15
Charge transfer per AP (pC)c 2.03 ± 1.14 0.31 ± 0.08 0.43 ± 0.23 0.29 ± 0.07
Failure rate of uIPSCb 0.68 ± 0.07 0.91 ± 0.02 0.59 ± 0.11 0.07 ± 0.05
Failure rate of uIPSC1c 0.20 ± 0.05 0.21 ± 0.07 0.39 ± 0.07 0.17 ± 0.07
Multiple-pulse depressiond 0.73 ± 0.15 0.68 ± 0.26 0.65 ± 0.05 0.44 ± 0.04
  • aData from rigorously confirmed CB1R+IN-to-GC (n = 5), HICAP-to-GC (n = 7), HIPP-to-GC (n = 4), and PV+BC-to-GC (n = 4) pairs.

  • buIPSCs were measured during the single firing mode, including failures.

  • cuIPSCs were measured during the burst firing mode, including failures.

  • dMultiple-pulse depression (25 Hz) was defined as IPSC5/IPSC1.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dentate gyrus hilar cell Dentate Gyrus GABA-ergic Non-fast spiking Cannabinoid receptor type 1-expressing Interneuron input resistance (MΩ) 303.0 ± 13.0 (5) 303.0 (MΩ) Data Table
Dentate gyrus HICAP cell Dentate Gyrus GABA-ergic Non-fast spiking C/A pathway-associated Interneuron input resistance (MΩ) 343.0 ± 18.0 343.0 (MΩ) Data Table
Dentate gyrus HIPP cell Dentate Gyrus GABA-ergic Non-fast spiking PP-associated axon terminal Interneuron input resistance (MΩ) 295.0 ± 48.0 (4) 295.0 (MΩ) Data Table
Dentate gyrus basket cell Dentate Gyrus GABA-ergic Fast spiking Parvalbumin-expressing Basket Interneuron input resistance (MΩ) 109.0 ± 20.0 (4) 109.0 (MΩ) Data Table
Dentate gyrus hilar cell Dentate Gyrus GABA-ergic Non-fast spiking Cannabinoid receptor type 1-expressing Interneuron membrane time constant (ms) 42.2 ± 3.2 (5) 42.2 (ms) Data Table
Dentate gyrus HICAP cell Dentate Gyrus GABA-ergic Non-fast spiking C/A pathway-associated Interneuron membrane time constant (ms) 45.9 ± 1.6 45.9 (ms) Data Table
Dentate gyrus HIPP cell Dentate Gyrus GABA-ergic Non-fast spiking PP-associated axon terminal Interneuron membrane time constant (ms) 40.8 ± 5.2 (4) 40.8 (ms) Data Table
Dentate gyrus hilar cell Dentate Gyrus GABA-ergic Non-fast spiking Cannabinoid receptor type 1-expressing Interneuron spike half-width (ms) 1.7 ± 0.1 (5) 1.7 (ms) Data Table
Dentate gyrus basket cell Dentate Gyrus GABA-ergic Fast spiking Parvalbumin-expressing Basket Interneuron membrane time constant (ms) 16.5 ± 2.6 (4) 16.5 (ms) Data Table
Dentate gyrus hilar cell Dentate Gyrus GABA-ergic Non-fast spiking Cannabinoid receptor type 1-expressing Interneuron first spike latency (ms) 3.4 ± 0.3 (5) 3.4 (ms) Data Table
Dentate gyrus HICAP cell Dentate Gyrus GABA-ergic Non-fast spiking C/A pathway-associated Interneuron first spike latency (ms) 3.8 ± 0.3 3.8 (ms) Data Table
Dentate gyrus HIPP cell Dentate Gyrus GABA-ergic Non-fast spiking PP-associated axon terminal Interneuron first spike latency (ms) 3.7 ± 0.4 (4) 3.7 (ms) Data Table
Dentate gyrus basket cell Dentate Gyrus GABA-ergic Fast spiking Parvalbumin-expressing Basket Interneuron first spike latency (ms) 1.6 ± 0.2 (4) 1.6 (ms) Data Table
Dentate gyrus hilar cell Dentate Gyrus GABA-ergic Non-fast spiking Cannabinoid receptor type 1-expressing Interneuron spike rise time (ms) 1.6 ± 0.4 (5) 1.6 (ms) Data Table
Dentate gyrus HICAP cell Dentate Gyrus GABA-ergic Non-fast spiking C/A pathway-associated Interneuron spike rise time (ms) 1.8 ± 0.3 1.8 (ms) Data Table
Dentate gyrus HIPP cell Dentate Gyrus GABA-ergic Non-fast spiking PP-associated axon terminal Interneuron spike rise time (ms) 2.5 ± 0.1 (4) 2.5 (ms) Data Table
Dentate gyrus HICAP cell Dentate Gyrus GABA-ergic Non-fast spiking C/A pathway-associated Interneuron spike half-width (ms) 1.7 ± 0.1 1.7 (ms) Data Table
Dentate gyrus basket cell Dentate Gyrus GABA-ergic Fast spiking Parvalbumin-expressing Basket Interneuron spike rise time (ms) 0.7 ± 0.1 (4) 0.7 (ms) Data Table
Dentate gyrus HIPP cell Dentate Gyrus GABA-ergic Non-fast spiking PP-associated axon terminal Interneuron spike half-width (ms) 1.9 ± 0.2 (4) 1.9 (ms) Data Table
Dentate gyrus basket cell Dentate Gyrus GABA-ergic Fast spiking Parvalbumin-expressing Basket Interneuron spike half-width (ms) 1.2 ± 0.1 (4) 1.2 (ms) Data Table