Article: Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortex.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Dougherty SE; Bartley AF; Lucas EK; Hablitz JJ; Dobrunz LE; Cowell RM Neuroscience, 2014
WT (9) | PGC-1α KO (13) | p-Value | WT (8) | PGC-1α KO (5) | p-Value | WT (2) | PGC-1α KO (8) | p-Value | |
---|---|---|---|---|---|---|---|---|---|
All PV INs | All PV INs | Fast-spiking | Fast-spiking | Non-fast-spiking | Non-fast-spiking | ||||
Resting potential (mV) | -58.56 | -55.92 | 0.610 | -56.00 | -65.60 | 0.163 | -56.00 | -48.63 | 0.317 |
Input resistance (MΩ) | 172.89 | 145.15 | 0.369 | 160.13 | 206.20 | 0.252 | 200.00 | 107.00 | 0.096 |
Spiking threshold (mV) | -44.09 | -39.79 | 0.037 | -43.63 | -44.01 | 0.666 | -43.04 | -37.77 | 0.149 |
Action potential amplitude (mV) | 59.66 | 51.74 | 0.073 | 54.27 | 54.39 | 0.979 | 64.60 | 46.29 | 0.019 |
Action potential half-width (ms) | 0.54 | 0.59 | 0.196 | 0.51 | 0.54 | 0.222 | 0.69 | 0.63 | 0.530 |
AHP (mV) | 17.87 | 17.06 | 0.063 | 17.41 | 21.68 | 0.007 | 19.87 | 14.31 | 0.334 |
Frequency at maximum current step (Hz) | 314.21 | 251.57 | 0.040 | 327.98 | 268.46 | 0.020 | 185.37 | 236.70 | 0.428 |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Neocortex basket cell | Motor cortex layer 5 fast spiking parvalbumin positive interneurons | input resistance (MΩ) | 160.13 (8) | 160.13 (MΩ) | Data Table |
Neocortex basket cell | Motor cortex layer 5 non fast spiking parvalbumin positive interneurons | input resistance (MΩ) | 200.0 (2) | 200.0 (MΩ) | Data Table |
Neocortex basket cell | Motor cortex layer 5 fast spiking parvalbumin positive interneurons | spike threshold (mV) | -43.63 (8) | -43.63 (mV) | Data Table |
Neocortex basket cell | Motor cortex layer 5 non fast spiking parvalbumin positive interneurons | spike threshold (mV) | -43.04 (2) | -43.04 (mV) | Data Table |
Neocortex basket cell | Motor cortex layer 5 fast spiking parvalbumin positive interneurons | spike amplitude (mV) | 54.27 (8) | 54.27 (mV) | Data Table |
Neocortex basket cell | Motor cortex layer 5 non fast spiking parvalbumin positive interneurons | spike amplitude (mV) | 64.6 (2) | 64.6 (mV) | Data Table |
Neocortex basket cell | Motor cortex layer 5 fast spiking parvalbumin positive interneurons | spike half-width (ms) | 0.51 (8) | 0.51 (ms) | Data Table |
Neocortex basket cell | Motor cortex layer 5 non fast spiking parvalbumin positive interneurons | spike half-width (ms) | 0.69 (2) | 0.69 (ms) | Data Table |
Neocortex basket cell | Motor cortex layer 5 fast spiking parvalbumin positive interneurons | resting membrane potential (mV) | -56.0 (8) | -56.0 (mV) | Data Table |
Neocortex basket cell | Motor cortex layer 5 fast spiking parvalbumin positive interneurons | AHP amplitude (mV) | 17.41 (8) | 17.41 (mV) | Data Table |
Neocortex basket cell | Motor cortex layer 5 non fast spiking parvalbumin positive interneurons | AHP amplitude (mV) | 19.87 (2) | 19.87 (mV) | Data Table |
Neocortex basket cell | Motor cortex layer 5 fast spiking parvalbumin positive interneurons | maximum firing rate (Hz) | 327.98 (8) | 327.98 (Hz) | Data Table |
Neocortex basket cell | Motor cortex layer 5 non fast spiking parvalbumin positive interneurons | maximum firing rate (Hz) | 185.37 (2) | 185.37 (Hz) | Data Table |
Neocortex basket cell | Motor cortex layer 5 non fast spiking parvalbumin positive interneurons | resting membrane potential (mV) | -56.0 (2) | -56.0 (mV) | Data Table |