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Article: Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Dougherty SE; Bartley AF; Lucas EK; Hablitz JJ; Dobrunz LE; Cowell RM
Neuroscience, 2014


WT (9)PGC-1α KO (13)p-ValueWT (8)PGC-1α KO (5)p-ValueWT (2)PGC-1α KO (8)p-Value
All PV INsAll PV INsFast-spikingFast-spikingNon-fast-spikingNon-fast-spiking
Resting potential (mV)-58.56-55.920.610-56.00-65.600.163-56.00-48.630.317
Input resistance (MΩ)172.89145.150.369160.13206.200.252200.00107.000.096
Spiking threshold (mV)-44.09-39.790.037-43.63-44.010.666-43.04-37.770.149
Action potential amplitude (mV)59.6651.740.07354.2754.390.97964.6046.290.019
Action potential half-width (ms)0.540.590.1960.510.540.2220.690.630.530
AHP (mV)17.8717.060.06317.4121.680.00719.8714.310.334
Frequency at maximum current step (Hz)314.21251.570.040327.98268.460.020185.37236.700.428

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell Motor cortex layer 5 fast spiking parvalbumin positive interneurons input resistance (MΩ) 160.13 (8) 160.13 (MΩ) Data Table
Neocortex basket cell Motor cortex layer 5 non fast spiking parvalbumin positive interneurons input resistance (MΩ) 200.0 (2) 200.0 (MΩ) Data Table
Neocortex basket cell Motor cortex layer 5 fast spiking parvalbumin positive interneurons spike threshold (mV) -43.63 (8) -43.63 (mV) Data Table
Neocortex basket cell Motor cortex layer 5 non fast spiking parvalbumin positive interneurons spike threshold (mV) -43.04 (2) -43.04 (mV) Data Table
Neocortex basket cell Motor cortex layer 5 fast spiking parvalbumin positive interneurons spike amplitude (mV) 54.27 (8) 54.27 (mV) Data Table
Neocortex basket cell Motor cortex layer 5 non fast spiking parvalbumin positive interneurons spike amplitude (mV) 64.6 (2) 64.6 (mV) Data Table
Neocortex basket cell Motor cortex layer 5 fast spiking parvalbumin positive interneurons spike half-width (ms) 0.51 (8) 0.51 (ms) Data Table
Neocortex basket cell Motor cortex layer 5 non fast spiking parvalbumin positive interneurons spike half-width (ms) 0.69 (2) 0.69 (ms) Data Table
Neocortex basket cell Motor cortex layer 5 fast spiking parvalbumin positive interneurons resting membrane potential (mV) -56.0 (8) -56.0 (mV) Data Table
Neocortex basket cell Motor cortex layer 5 fast spiking parvalbumin positive interneurons AHP amplitude (mV) 17.41 (8) 17.41 (mV) Data Table
Neocortex basket cell Motor cortex layer 5 non fast spiking parvalbumin positive interneurons AHP amplitude (mV) 19.87 (2) 19.87 (mV) Data Table
Neocortex basket cell Motor cortex layer 5 fast spiking parvalbumin positive interneurons maximum firing rate (Hz) 327.98 (8) 327.98 (Hz) Data Table
Neocortex basket cell Motor cortex layer 5 non fast spiking parvalbumin positive interneurons maximum firing rate (Hz) 185.37 (2) 185.37 (Hz) Data Table
Neocortex basket cell Motor cortex layer 5 non fast spiking parvalbumin positive interneurons resting membrane potential (mV) -56.0 (2) -56.0 (mV) Data Table