Article: Stimulation of D1-type dopamine receptors enhances excitability in prefrontal cortical pyramidal neurons in a state-dependent manner.
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Lavin A; Grace AA
Neuroscience, 2001
| | Control (n=10) | Dopamine |
|---|
| Membrane potential (mV) | Up state | 65.8±7.2 | 60.4±7.2 |
| Down state | 85.5±7.0 | 79.1±7.0 |
| Spike threshold (mV) | Up state | 46.8±7.1 | 44.4±4.8 |
| Down state | 50.2±8.9 | 45.8±6.3 |
| Current threshold (pA) | Up state | 29.8±14.6 | 21.3±8.4 |
| Down state | 45±21* | 37±14 |
| Spike amplitude (mV) | Up state | 62.7±1.3 | 58.9±1.2 |
| Down state | 62.9±1.4 | 62.0±0.8 |
| Amplitude AHP (mV) | Up state | 6.0±4.2 | 7.2±2.3 |
| Down state | 5.9±2.9 | 8.1±1.4+ |
| Input resistance (MΩ) | Up state | 75.2±21.0 | 60.9±13.8 |
| Down state | 66.1±20.2 | 72.3±25.2 |
| Excitability (slope #spikes/IpA) | Up state | 0.107±0.07 | 0.242±0.09** |
| Down state | 0.07±0.04 | 0.113±0.069 |
Inferred neuron-electrophysiology data values
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