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Article: Characterization of M-current in ventral tegmental area dopamine neurons.

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Koyama S; Appel SB
J. Neurophysiol., 2006



TABLE 2.Effect of XE991 on the shape of the evoked action potential (AP) in DA VTA neurons


Control (7) XE991, 1 µM (7) Control (6) XE991, 3 µM (6) Control (7) XE991, 10 µM (7)

Amplitude, mV 86.1 ± 2.0 87.0 ± 2.0 87.8 ± 2.1 88.7 ± 2.2 87.6 ± 1.2 87.2 ± 1.5
Half-width, ms 1.3 ± 0.1 1.3 ± 0.1 1.1 ± 0.1 1.1 ± 0.1 1.2 ± 0.1 1.3 ± 0.1
Threshold, mV –42.7 ± 0.9 –42.8 ± 0.8 –42.7 ± 1.0 –42.4 ± 1.1 –42.8 ± 1.2 –42.9 ± 1.4
AHP-1, mV 25.6 ± 1.5 24.0 ± 1.3* 27.3 ± 1.9 25.1 ± 1.7** 27.5 ± 1.1 22.5 ± 1.5**
AHP-2, mV 26.6 ± 2.8 26.6 ± 3.1 27.8 ± 3.8 28.6 ± 2.4 25.5 ± 4.1 24.4 ± 4.4
AHP-3, mV 16.6 ± 1.0 15.7 ± 1.0* 16.5 ± 1.5 14.8 ± 1.4* 15.0 ± 1.2 11.2 ± 2.3**

Values are means ± SE. Numbers of neurons (n) are in parentheses. AHP, spike afterhyperpolarization. All AP shape parameters were analyzed on the first AP evoked by a 10-pA depolarizing current injection (see Fig. 4, A1 and B). APs were evoked from the same membrane potential before and after XE991 treatment. DC current injection was used to keep the membrane potential constant. Statistical significance was assessed with the paired Student's t-test. The asterisks indicate significant differences between values in control and in the presence of XE991 (

* P < 0.05;

** P < 0.01).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Ventral tegmental area dopamine neuron spike amplitude (mV) 86.1 ± 2.0 (7) 86.1 (mV) Data Table
Ventral tegmental area dopamine neuron spike half-width (ms) 1.3 ± 0.1 (7) 1.3 (ms) Data Table
Ventral tegmental area dopamine neuron spike threshold (mV) -42.7 ± 0.9 (7) -42.7 (mV) Data Table
Ventral tegmental area dopamine neuron AHP amplitude (mV) 25.6 ± 1.5 (7) 25.6 (mV) Data Table