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Article: Repeated cocaine exposure increases fast-spiking interneuron excitability in the rat medial prefrontal cortex.

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Campanac E; Hoffman DA
J. Neurophysiol., 2013


Table 1.

Passive and active membrane properties of FS-IN in layer 5 mPFC neurons from saline- and cocaine-treated rats after long-term withdrawal

PretreatmentSalineCocaineP Value
n1918
Passive membrane properties
RMP, mV-78.03 ± 0.98-75.76 ± 0.91ns
Input resistance, MΩ103.58 ± 4.65131.25 ± 8.29<0.05*
Active membrane properties
Rheobase, pA258.60 ± 13.41169.63 ± 13.46<0.001*
First spike parameters @ rheobase
    Onset, ms206.72 ± 51.79258.78 ± 49.98ns
    Threshold, mV-40.73 ± 1.07-41.28 ± 3.36ns
    Rise time 10-90%, ms0.29 ± 0.010.33 ± 0.04ns
    Maximum, mV9.86 ± 1.3813.01 ± 1.56ns
    AHP amplitude, mV-21.72 ± 1.03-19.79 ± 0.88ns
    Width, ms0.56 ± 0.020.54 ± 0.01ns
First spike parameters @ 15-Hz firing
    Onset, ms42.19 ± 16.8770.02 ± 29.59ns
    Threshold, mV-44.64 ± 1.35-46.84 ± 1.44ns
    Rise time 10-90%, ms0.34 ± 0.040.34 ± 0.03ns
    Maximum, mV9.05 ± 1.7511.16 ± 1.65ns
    AHP amplitude, mV-15.78 ± 1.24-16.32 ± 1.61ns
    Width, ms0.57 ± 0.020.55 ± 0.0ns
    Accommodation index13.08 ± 4.015.36 ± 1.34ns
  • Values are means ± SE; n, no. of neurons (saline, n = 19, 8 rats; cocaine, n = 18, 7 rats). RMP, resting membrane potential; AHP, afterhyperpolarization. Parameters of the first spike were measured during step current injections corresponding at the rheobase or when neurons fired at approximately 15 Hz (i.e., 12-18 action potentials during the 1-s current step). Accommodation is defined by (tspike 2 - tspike 1)/(tspike n - tspike n-1), where t is time.

  • * Significant difference. ns, Not significant.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex interneuron deep Medial prefrontal cortex layer V fast-spiking interneurons input resistance (MΩ) 103.58 ± 4.65 (19) 103.58 (MΩ) Data Table
Neocortex interneuron deep Medial prefrontal cortex layer V fast-spiking interneurons rheobase (pA) 258.6 ± 13.41 (19) 258.6 (pA) Data Table
Neocortex interneuron deep Medial prefrontal cortex layer V fast-spiking interneurons spike threshold (mV) -40.73 ± 1.07 (19) -40.73 (mV) Data Table
Neocortex interneuron deep Medial prefrontal cortex layer V fast-spiking interneurons spike rise time (ms) 0.29 ± 0.01 (19) 0.29 (ms) Data Table
Neocortex interneuron deep Medial prefrontal cortex layer V fast-spiking interneurons input resistance (mV) 9.86 ± 1.38 (19) -- Data Table
Neocortex interneuron deep Medial prefrontal cortex layer V fast-spiking interneurons AHP amplitude (mV) -21.72 ± 1.03 (19) 21.72 (mV) Data Table
Neocortex interneuron deep Medial prefrontal cortex layer V fast-spiking interneurons spike half-width (ms) 0.56 ± 0.02 (19) 0.56 (ms) Data Table
Neocortex interneuron deep Medial prefrontal cortex layer V fast-spiking interneurons spike peak (mV) 9.05 ± 1.75 (19) 9.05 (mV) Data Table
Neocortex interneuron deep Medial prefrontal cortex layer V fast-spiking interneurons resting membrane potential (mV) -78.03 ± 0.98 (19) -78.03 (mV) Data Table
Neocortex interneuron deep Medial prefrontal cortex layer V fast-spiking interneurons adaptation ratio (other) 13.08 ± 4.01 (19) 13.08 (None) Data Table