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Article: Electrophysiological properties of genetically identified subtypes of layer 5 neocortical pyramidal neurons: Ca²⁺ dependence and differential modulation by norepinephrine.

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Guan D; Armstrong WE; Foehring RC
J. Neurophysiol., 2015


Table 2.

Single AP parameters

AP, mVVth, mVHW, msdV/dt up, V/sdV/dt down, V/s
Etv1100 ± 2 (71)-49 ± 1 (69)1.0 ± 0.03 (71)310 ± 10 (71)105 ± 3 (71)
Glt2598 ± 2 (57)-52 ± 1 (57)*0.9 ± 0.02 (57)*352 ± 12 (57)*125 ± 7 (35)*
Layer 2/3112 ± 2 (23)-52 ± 1 (23)1.2 ± 0.04 (23)331 ± 13 (23)89 ± 4 (23)
  • Data are presented as means ± SE (n, number of cells).

  • * Glt significantly different from etv1 (P < 0.05, unpaired t-test).

  • Significantly different from layer 2/3 (ANOVA plus post hoc test). AP, action potential amplitude; Vth, voltage threshold; HW, AP width at half amplitude (from resting potential); dV/dt up, maximum rate of AP rise; dV/dt down, maximum rate of AP repolarization.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons spike amplitude from resting (mV) 100.0 ± 2.0 (71) 100.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons spike threshold (mV) -49.0 ± 1.0 (69) -49.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons spike half-width (ms) 1.0 ± 0.03 (71) 1.0 (ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons spike max rise slope (V/s) 310.0 ± 10.0 (71) 310.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5a corticostriatal Etv1-expressing slender-tufted pyramidal neurons spike max decay slope (V/s) 105.0 ± 3.0 (71) 105.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons spike amplitude from resting (mV) 98.0 ± 2.0 (57) 98.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons spike threshold (mV) -52.0 ± 1.0 (57) -52.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons spike half-width (ms) 0.9 ± 0.02 (57) 0.9 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons spike max rise slope (V/s) 352.0 ± 12.0 (57) 352.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5b Glt25d2-expressing thick-tufted pyramidal neurons spike max decay slope (V/s) 125.0 ± 7.0 (35) 125.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons spike amplitude from resting (mV) 112.0 ± 2.0 (23) 112.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons spike threshold (mV) -52.0 ± 1.0 (23) -52.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons spike half-width (ms) 1.2 ± 0.04 (23) 1.2 (ms) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons spike max rise slope (V/s) 331.0 ± 13.0 (23) 331.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 2-3 somatosensory cortex layer 2/3 pyramidal neurons spike max decay slope (V/s) 89.0 ± 4.0 (23) 89.0 (mV/ms) Data Table