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Article: Electrophysiological classification of somatostatin-positive interneurons in mouse sensorimotor cortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Halabisky B; Shen F; Huguenard JR; Prince DA
J. Neurophysiol., 2006



TABLE 2.Electrophysiological properties of four types of EGFP-expressing cells


Group 1 (n = 17) Group 2 (n = 7) Group 3 (n = 15) Group 4 (n = 7)

Groups 1, 2, 3 >> 4; Groups 1, 2 > 3
AHP shape, mV 1.6 ± 0.8 1.7 ± 1.0 0.8 ± 0.7 –3.6 ± 0.6
Group 3 >> Groups 1, 2; Group 3 > Group 4
Steady-state firing frequency, Hz 36.2 ± 9.6 28.8 ± 9.0 56.6 ± 17.5 37.2 ± 13.0
Group 1 >> Group 4; Group 2 >> Groups 1, 3, 4
Membrane time constant, ms 20.5 ± 6.5 31.4 ± 7.7 15.3 ± 3.4 9.8 ± 3.3
Group 3 >> Groups 1, 2, 4
Sag conductance, nS 1.7 ± 1.2 0.51 ± 0.72 3.9 ± 1.2 0.95 ± 1.0
Group 1 >> Groups 2, 3
sEPSC peak amplitude, pA –18.1 ± 4.2 –31.1 ± 7.2 –25.7 ± 7.3 –25.1 ± 7.2
Group 1 > Groups 2, 4
sEPSC rise time, ms 1.9 ± 0.4 1.4 ± 0.4 1.6 ± 0.3 1.4 ± 0.1
Group 1 >> Groups 2, 3, 4
sEPSC decay time, ms 8.2 ± 1.4 5.0 ± 1.4 6.3 ± 1.5 4.8 ± 1.3
Groups not significantly different (P > 0.1)
Input resistance, MΩ 205 ± 30 224 ± 19 212 ± 27 213 ± 19
Groups not significantly different (P > 0.1)
Resting membrane potential, mV –58.7 ± 3.6 –59.0 ± 2.7 –57.2 ± 3.3 –60.9 ± 3.8
Groups not significantly different (P > 0.5)
Series resistance MΩ 36.2 ± 9.6 28.8 ± 9.0 56.6 ± 17.5 37.2 ± 13.0
Groups not significantly different (P > 0.1)
f–I terminal slope Hz/nA 36.2 ± 9.6 28.8 ± 9.0 56.6 ± 17.5 37.2 ± 13.0

Values are means ± SD, n, number of cells; >, significantly greater with P = 0.05; >>, significantly greater with P = 0.01. Statistically significant differences were determined using a Tukey post hoc means analysis after performing ANOVA. Electrophysiological parameters were measured as described in METHODS.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 1 cell firing frequency (Hz) 36.2 ± 9.6 (17) 36.2 (Hz) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 2 cell firing frequency (Hz) 28.8 ± 9.0 (7) 28.8 (Hz) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 3 cell firing frequency (Hz) 56.6 ± 17.5 (15) 56.6 (Hz) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 4 cell firing frequency (Hz) 37.2 ± 13.0 (7) 37.2 (Hz) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 1 cell membrane time constant (ms) 20.5 ± 6.5 (17) 20.5 (ms) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 2 cell membrane time constant (ms) 31.4 ± 7.7 (7) 31.4 (ms) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 3 cell membrane time constant (ms) 15.3 ± 3.4 (15) 15.3 (ms) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 4 cell membrane time constant (ms) 9.8 ± 3.3 (7) 9.8 (ms) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 1 cell input resistance (MΩ) 205.0 ± 30.0 (17) 205.0 (MΩ) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 2 cell input resistance (MΩ) 224.0 ± 19.0 (7) 224.0 (MΩ) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 3 cell input resistance (MΩ) 212.0 ± 27.0 (15) 212.0 (MΩ) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 4 cell input resistance (MΩ) 213.0 ± 19.0 (7) 213.0 (MΩ) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 1 cell resting membrane potential (mV) -58.7 ± 3.6 (17) -58.7 (mV) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 2 cell resting membrane potential (mV) -59.0 ± 2.7 (7) -59.0 (mV) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 3 cell resting membrane potential (mV) -57.2 ± 3.3 (15) -57.2 (mV) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 4 cell resting membrane potential (mV) -60.9 ± 3.8 (7) -60.9 (mV) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 1 cell access resistance (MΩ) 36.2 ± 9.6 (17) 36.2 (MΩ) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 2 cell access resistance (MΩ) 28.8 ± 9.0 (7) 28.8 (MΩ) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 3 cell access resistance (MΩ) 56.6 ± 17.5 (15) 56.6 (MΩ) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 4 cell access resistance (MΩ) 37.2 ± 13.0 (7) 37.2 (MΩ) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 1 cell FI slope (Hz/nA) 36.2 ± 9.6 (17) 36.2 (Hz/nA) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 2 cell FI slope (Hz/nA) 28.8 ± 9.0 (7) 28.8 (Hz/nA) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 3 cell FI slope (Hz/nA) 56.6 ± 17.5 (15) 56.6 (Hz/nA) Data Table
Neocortex Martinotti cell sensorimotor cortex layer 2/3 somatostatin-expressing group 4 cell FI slope (Hz/nA) 37.2 ± 13.0 (7) 37.2 (Hz/nA) Data Table