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Article: Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Liu Y; Harding M; Pittman A; Dore J; Striessnig J; Rajadhyaksha A; Chen X J. Neurophysiol., 2014
Table 2.
Burst properties of dopaminergic cells in wild type (WT), Cav1.2DHP-/- and Cav1.3-/- mice
| (S)-(-)-Bay K8644 | FPL 64176 | |||||||
|---|---|---|---|---|---|---|---|---|
| wild type (WT)1 | Cav1.2DHP-/-2 | P1,2 | wild type (WT)1 | Cav1.2DHP-/-2 | Cav1.3-/-3 | P1,2 | P1,3 | |
| Number of bursting cells after drug application | 7 of 12 | 7 of 14 | >0.05 | 11 of 16 | 7 of 14 | 10 of 22 | >0.05 | >0.05 |
| Lag between the start of drug application and bursting (min) | 9-37 | 16-40 | 11-40 | 13-42 | 14-50 | |||
| Average lag time (min) | 22 ± 4.5 | 26 ± 3.5 | >0.05 | 24 ± 3.4 | 21 ± 3.6 | 29 ± 2.5 | >0.05 | >0.05 |
| Number of long-lasting (>30 min) bursting cells | 7 of 7 | 6 of 7 | >0.05 | 11 of 11 | 6 of 7 | 6 of 10 | >0.05 | <0.05 |
| Number of inhibited cell by 10 μM nifedipine | 6 of 6 | 6 of 6 | >0.05 | 6 of 6 | 6 of 6 | 6 of 6 | >0.05 | >0.05 |
| number of spikes in bursts | 3-6 | 2-13 | 2-9 | 2-20 | 2-19 | |||
| average number of spikes | 4.14 ± 0.46 | 4.39 ± 1.18 | >0.05 | 4.28 ± 0.79 | 4.45 ± 1.12 | 5.06 ± 1.46 | >0.05 | >0.05 |
| firing frequency before bursts (Hz) | 0.11 ± 0.08 | 0.45 ± 0.16 | >0.05 | 0.75 ± 0.17 | 0.29 ± 0.12 | 0.0014 ± 0.003 | >0.05 | >0.05 |
| firing frequency in the bursts (Hz) | 1.17 ± 0.27 | 1.38 ± 0.32 | >0.05 | 2.01 ± 0.44 | 5.91 ± 4.55 | 2.26 ± 1.08 | >0.05 | >0.05 |
| bursts frequency (Hz) | 0.06 ± 0.03 | 0.10 ± 0.05 | >0.05 | 0.12 ± 0.04 | 0.20 ± 0.07 | 0.04 ± 0.01 | >0.05 | >0.05 |
| interspike interval of spikes in burst (sec) | 1.02 ± 0.19 | 0.93 ± 0.16 | >0.05 | 0.68 ± 0.17 | 0.76 ± 0.22 | 1.50 ± 0.33 | >0.05 | >0.05 |
| interburst interval (sec) | 24.86 ± 8.27 | 20.44 ± 4.68 | >0.05 | 13.86 ± 3.74 | 13.16 ± 5.49 | 32.43 ± 5.04 | >0.05 | >0.05 |
Values are means ± SE.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|