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Article: Dopamine neurons in the ventral tegmental area fire faster in adolescent rats than in adults.

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McCutcheon JE; Conrad KL; Carr SB; Ford KA; McGehee DS; Marinelli M
J. Neurophysiol., 2012


Table 2.

Electrophysiological properties of VTA dopamine neurons recorded in an ex vivo midbrain slice preparation from adolescent and adult rats

AdolescentAdultP Value
Cell-attached properties
    Mean firing rate, Hz2.22 ± 0.12 (47)1.82 ± 0.11 (42)0.020*
    ISI, mean, ms533.56 ± 36.09 (47)688.94 ± 69.64 (42)0.044*
    ISI, mode, ms518.94 ± 32.93 (47)672.14 ± 69.07 (42)0.041*
    CV of firing rate0.15 ± 0.01 (47)0.14 ± 0.02 (42)0.748
    AP width, ms2.01 ± 0.17 (47)2.32 ± 0.21 (42)0.230
Passive membrane properties
    Resting membrane potential, mV-41.97 ± 1.41 (12)-42.75 ± 1.73 (12)0.729
    Input resistance, MΩ264.85 ± 30.84 (12)219.48 ± 54.82 (12)0.478
    Capacitance, pF64.78 ± 6.85 (11)58.82 ± 7.94 (9)0.575
Action potential properties
    Amplitude, mV80.06 ± 2.74 (12)75.35 ± 2.88 (12)0.249
    Threshold, mV-26.25 ± 1.32 (12)-26.39 ± 1.72 (12)0.947
    Half-width, ms1.09 ± 0.14 (12)1.15 ± 0.15 (12)0.753
    AHP amplitude, mV-22.03 ± 1.45 (12)-21.55 ± 1.49 (12)0.820
Ih properties
    Iins, pA267.21 ± 36.93 (9)399.13 ± 82.10 (8)0.174
    Iss, pA593.08 ± 112.06 (9)762.73 ± 109.56 (8)0.296
    Ih amplitude (Iss - Iins), pA325.87 ± 83.43 (9)363.60 ± 88.44 (8)0.761
    Iins charge transfer, pC204.02 ± 28.61 (9)297.56 ± 59.38 (8)0.186
    Ih charge transfer, pC182.79 ± 51.11 (9)197.43 ± 49.52 (8)0.840
    Ih activation time, ms282.13 ± 42.34 (9)257.73 ± 23.16 (8)0.622
SK properties
    Amplitude, pA166.2 ± 45.6 (10)160.9 ± 58.5 (6)0.943
    Decay time, ms265.6 ± 38.7 (10)239.9 ± 57.2 (6)0.704

  • ↵Values are means ± SE with n in parentheses. P values after 2-tailed Student's t-test are given for adolescent vs. adult rats for each parameter (*P ≤ 0.05). AP, action potential; AHP, afterhyperpolarization; Ih, hyperpolarization-activated cation current; Iins, instantaneous current; Iss, steady-state current; SK, small-conductance calcium-activated potassium current.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Ventral tegmental area dopamine neuron cell capacitance (pF) 64.78 ± 6.85 (11) 64.78 (pF) Data Table
Ventral tegmental area dopamine neuron cell capacitance (pF) 58.82 ± 7.94 (9) 58.82 (pF) Data Table
Ventral tegmental area dopamine neuron spike amplitude (mV) 80.06 ± 2.74 (12) 80.06 (mV) Data Table
Ventral tegmental area dopamine neuron spike amplitude (mV) 75.35 ± 2.88 (12) 75.35 (mV) Data Table
Ventral tegmental area dopamine neuron spike threshold (mV) -26.25 ± 1.32 (12) -26.25 (mV) Data Table
Ventral tegmental area dopamine neuron spike threshold (mV) -26.39 ± 1.72 (12) -26.39 (mV) Data Table
Ventral tegmental area dopamine neuron spike half-width (ms) 1.09 ± 0.14 (12) 1.09 (ms) Data Table
Ventral tegmental area dopamine neuron spike half-width (ms) 1.15 ± 0.15 (12) 1.15 (ms) Data Table
Ventral tegmental area dopamine neuron AHP amplitude (mV) -22.03 ± 1.45 (12) 22.03 (mV) Data Table
Ventral tegmental area dopamine neuron AHP amplitude (mV) -21.55 ± 1.49 (12) 21.55 (mV) Data Table
Ventral tegmental area dopamine neuron resting membrane potential (mV) -41.97 ± 1.41 (12) -41.97 (mV) Data Table
Ventral tegmental area dopamine neuron resting membrane potential (mV) -42.75 ± 1.73 (12) -42.75 (mV) Data Table
Ventral tegmental area dopamine neuron input resistance (MΩ) 264.85 ± 30.84 (12) 264.85 (MΩ) Data Table
Ventral tegmental area dopamine neuron input resistance (MΩ) 219.48 ± 54.82 (12) 219.48 (MΩ) Data Table