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Article: Examining protection from anoxic depolarization by the drugs dibucaine and carbetapentane using whole-cell recording from CA1 neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) None J. Neurophysiol., 2012
Table 1.
Anoxic depolarization properties recorded in CA1 pyramidal cells evoked by oxygen/glucose deprivation
| Control (n = 17) | 10 μM Dib (n = 11) | 100 μM Dib (n = 14) | Effect | |
|---|---|---|---|---|
| Fast AD ampl, mV | 28.8 ± 6.2 | 26.1 ± 10.2 | 18.9 ± 6.9* | Reduced |
| Peak potential, mV | -9.4 ± 4.6 | -15.4 ± 11.0 | -23.4 ± 11.2† | Reduced |
| Slope of fast AD, mV/s | 2.7 ± 1.5 | 2.1 ± 1.6 | 1.5 ± 0.4* | Reduced |
| Slope of slow depol, mV/s | 0.28 ± 0.16 | 0.18 ± 0.06 | 0.16 ± 0.04* | Reduced |
| Late AD duration, s | 46.4 ± 31.3 | 73.2 ± 37.2* | 124.5 ± 50.9† | Increased |
Values are means ± SD.
↵* P < 0.05;
↵† P < 0.01. Dib, dibucaine; fast AD ampl, amplitude of fast component of anoxic depolarization (AD); peak potential, peak amplitude of the depolarization; slope of fast AD, slope of the fast component of AD; slope of slow depol, slope of slow component of depolarization; late AD duration, duration of the late or persistent depolarization.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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