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Article: Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex.

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Yekhlef L; Breschi GL; Lagostena L; Russo G; Taverna S
J. Neurophysiol., 2015


Table 1.

Electrophysiological intrinsic properties of PV and SOM interneurons and pyramidal cells recorded in layer III of medial entorhinal cortex

PV (n = 18)SOM (n = 12)PC (n = 30)
rmp, mV-69 ± 1-61 ± 2*-68 ± 1
Rin, MΩ145 ± 16259 ± 35*175 ± 11
ΔV sag, mV2 ± 0.512 ± 3*2 ± 0.2
Spike width, ms0.7 ± 0.10.7 ± 0.11.7 ± 0.1*
AP amp, mV65 ± 2*72 ± 2*80 ± 2*
AHP amplitude, mV13 ± 116 ± 17.5 ± 0.4*
Spike threshold, mV-50 ± 1-51 ± 1-46 ± 1*
  • Values are means ± SE.

  • PV, parvalbumin-positive interneuron; SOM, somatostatin-positive interneuron; PC, pyramidal cell; rmp, resting membrane potential, Rin, input resistance, ΔV sag, amplitude of Ih-dependent depolarization, AP, action potential; AHP, afterhyperpolarized potential.

  • * Statistically significant difference (P < 0.05, unpaired t-test).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Medial entorhinal cortex layer 3 parvalbumin positive interneuron sag amplitude (mV) 2.0 ± 0.5 (18) 2.0 (mV) Data Table
Other Medial entorhinal cortex layer 3 somatostatin positive interneurons sag amplitude (mV) 12.0 ± 3.0 (12) 12.0 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell sag amplitude (mV) 2.0 ± 0.2 (30) 2.0 (mV) Data Table
Other Medial entorhinal cortex layer 3 parvalbumin positive interneuron spike half-width (ms) 0.7 ± 0.1 (18) 0.7 (ms) Data Table
Other Medial entorhinal cortex layer 3 somatostatin positive interneurons spike half-width (ms) 0.7 ± 0.1 (12) 0.7 (ms) Data Table
Medial entorhinal cortex layer III pyramidal cell spike half-width (ms) 1.7 ± 0.1 (30) 1.7 (ms) Data Table
Other Medial entorhinal cortex layer 3 parvalbumin positive interneuron spike amplitude (mV) 65.0 ± 2.0 (18) 65.0 (mV) Data Table
Other Medial entorhinal cortex layer 3 somatostatin positive interneurons spike amplitude (mV) 72.0 ± 2.0 (12) 72.0 (mV) Data Table
Other Medial entorhinal cortex layer 3 parvalbumin positive interneuron resting membrane potential (mV) -69.0 ± 1.0 (18) -69.0 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell spike amplitude (mV) 80.0 ± 2.0 (30) 80.0 (mV) Data Table
Other Medial entorhinal cortex layer 3 parvalbumin positive interneuron AHP amplitude (mV) 13.0 ± 1.0 (18) 13.0 (mV) Data Table
Other Medial entorhinal cortex layer 3 somatostatin positive interneurons AHP amplitude (mV) 16.0 ± 1.0 (12) 16.0 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell AHP amplitude (mV) 7.5 ± 0.4 (30) 7.5 (mV) Data Table
Other Medial entorhinal cortex layer 3 parvalbumin positive interneuron spike threshold (mV) -50.0 ± 1.0 (18) -50.0 (mV) Data Table
Other Medial entorhinal cortex layer 3 somatostatin positive interneurons spike threshold (mV) -51.0 ± 1.0 (12) -51.0 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell spike threshold (mV) -46.0 ± 1.0 (30) -46.0 (mV) Data Table
Other Medial entorhinal cortex layer 3 somatostatin positive interneurons resting membrane potential (mV) -61.0 ± 2.0 (12) -61.0 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell resting membrane potential (mV) -68.0 ± 1.0 (30) -68.0 (mV) Data Table
Other Medial entorhinal cortex layer 3 parvalbumin positive interneuron input resistance (MΩ) 145.0 ± 16.0 (18) 145.0 (MΩ) Data Table
Other Medial entorhinal cortex layer 3 somatostatin positive interneurons input resistance (MΩ) 259.0 ± 35.0 (12) 259.0 (MΩ) Data Table
Medial entorhinal cortex layer III pyramidal cell input resistance (MΩ) 175.0 ± 11.0 (30) 175.0 (MΩ) Data Table