Article: Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Yekhlef L; Breschi GL; Lagostena L; Russo G; Taverna S J. Neurophysiol., 2015
PV (n = 18) | SOM (n = 12) | PC (n = 30) | |
---|---|---|---|
rmp, mV | -69 ± 1 | -61 ± 2* | -68 ± 1 |
Rin, MΩ | 145 ± 16 | 259 ± 35* | 175 ± 11 |
ΔV sag, mV | 2 ± 0.5 | 12 ± 3* | 2 ± 0.2 |
Spike width, ms | 0.7 ± 0.1 | 0.7 ± 0.1 | 1.7 ± 0.1* |
AP amp, mV | 65 ± 2* | 72 ± 2* | 80 ± 2* |
AHP amplitude, mV | 13 ± 1 | 16 ± 1 | 7.5 ± 0.4* |
Spike threshold, mV | -50 ± 1 | -51 ± 1 | -46 ± 1* |
Values are means ± SE.
PV, parvalbumin-positive interneuron; SOM, somatostatin-positive interneuron; PC, pyramidal cell; rmp, resting membrane potential, Rin, input resistance, ΔV sag, amplitude of Ih-dependent depolarization, AP, action potential; AHP, afterhyperpolarized potential.
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↵* Statistically significant difference (P < 0.05, unpaired t-test).