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Article: Perineuronal Nets Suppress Plasticity of Excitatory Synapses on CA2 Pyramidal Neurons.

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Carstens KE; Phillips ML; Pozzo-Miller L; Weinberg RJ; Dudek SM
J. Neurosci., 2016


Table 1.

Intrinsic properties of CA2 pyramidal neurons in response to PNN degradation

Intrinsic properties
Resting membrane potential Membrane capacitance Neuron input resistance Decay time
CA2 control -63.75 ± 1.05 mV 143.1 ± 9.7 pF 303.5 ± 10.0 MΩ 1.796 ± 0.088 ms
CA2 ChABC -66.17 ± 0.83 mV 160.9 ± 7.9 pF 259.0 ± 10.5 MΩ* 1.856 ± 0.064 ms
  • CA2 neuron input resistance was significantly decreased after 0.05 U/ml ChABC treatment (n = 11 per group,

  • *p < 0.0043, two-tailed unpaired t test). Significant effects were not detected in other properties, including resting membrane potential, membrane capacitance, and decay time. Indicated are the means ± SEM.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA2 pyramidal neuron resting membrane potential -63.75 ± 1.05 -63.75 (mV) Data Table
Hippocampus CA2 pyramidal neuron cell capacitance 143.1 ± 9.7 143.1 (pF) Data Table
Hippocampus CA2 pyramidal neuron input resistance 303.5 ± 10.0 303.5 (MΩ) Data Table
Hippocampus CA2 pyramidal neuron spike decay time 1.796 ± 0.088 1.796 (ms) Data Table