Article: Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders.

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Zhang W; Zhang L; Liang B; Schroeder D; Zhang ZW; Cox GA; Li Y; Lin DT
Nat. Neurosci., 2016

From figure legend of Supplementary Figure 1 : Selective impairments in GABAergic transmission in L5-PNs of TDP mice.
	resting membrane potential (mV)	action potential threshold (mV)	input resistance (Mohm)
WT (n = 29)	–62.5 ± 1.6	–40 ± 0.9	92.6 ± 5.0
TDP (n = 25)	–61.6 ± 1.0	–41.6 ± 1.3	92.1 ± 4.7
: (e) Intrinsic membrane properties of L5-PNs in M1 of TDP mice were not different from WT mice, including resting membrane potential (WT, –62.5 ± 1.6 mV; TDP, –61.6 ± 1.0 mV; Mann-Whitney U-test, p = 0.65, z(52) = 0.39), action potential (AP) threshold (WT, –40 ± 0.9 mV; TDP, –41.6 ± 1.3 mV, Mann-Whitney U-test, p = 0.53, z(52) = 0.66), and input resistance (WT, 92.6 ± 5.0 MΩ; TDP, 92.1 ± 4.7 MΩ, Mann-Whitney U-test, p = 0.96, z(52) = 0.05). Recordings are from 3 TDP mice (n = 29 neurons) and 3 WT mice (n = 25 neurons). Data are presented as mean ± s.e.m. *, p 0.05. Data are from 20-22 day old mice.

Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Neocortex pyramidal cell layer 5-6	primary motor cortex layer 5 corticospinal thick tufted pyramidal cell	resting membrane potential (mV)	-62.5 ± 1.6 (29)	-62.5 (mV)	Data Table
Neocortex pyramidal cell layer 5-6	primary motor cortex layer 5 corticospinal thick tufted pyramidal cell	spike threshold (mV)	-40.0 ± 0.9 (29)	-40.0 (mV)	Data Table
Neocortex pyramidal cell layer 5-6	primary motor cortex layer 5 corticospinal thick tufted pyramidal cell	input resistance (Mohm)	92.6 ± 5.0 (29)	92.6 (MΩ)	Data Table