Article: A comparative voltage and current-clamp analysis of feedback and feedforward synaptic transmission in the striatal microcircuit in vitro.

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Gustafson N; Gireesh-Dharmaraj E; Czubayko U; Blackwell KT; Plenz D
J. Neurophysiol., 2006

TABLE 1.Electrophysiological parameters for SP neurons and FS interneurons from mature cortex-striatum-substantia nigra cultures



Response Parameter	SP Neuron	FS Interneuron

Number of cells	92	48
Resting membrane potential, mV	–78.6 ± 0.38	–61.8 ± 1.10^†
Input resistance MΩ	338 ± 18	313 ± 52^†
Time constant ms	10.9 ± 0.72	8.3 ± 0.90^*
AP threshold, mV	–27.0 ± 0.6	–26.9 ± 0.9
AP amplitude, mV	70.2 ± 0.9	60.4 ± 1.5^†
AP width, ms	1.12 ± 0.04	0.65 ± 0.05^†
AHP amplitude, mV	14.3 ± 0.5	20.3 ± 0.8^†
AHP time, ms	12.3 ± 0.5	4.1 ± 0.55^†

Values are mean ± SE.

^* P < 0.05;

^† P < 0.005. SP, spiny projection; FS, fast spiking; AP, action potential; AHP, afterhyperpolarization.

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Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source
Neostriatum medium spiny neuron		resting membrane potential (mV)	-78.6 ± 0.38 (92)	-78.6 (mV)	Data Table
Substantia nigra pars reticulata interneuron GABA	fast-spiking interneuron	resting membrane potential (mV)	-61.8 ± 1.1 (48)	-61.8 (mV)	Data Table
Neostriatum medium spiny neuron		input resistance (MΩ)	338.0 ± 18.0 (92)	338.0 (MΩ)	Data Table
Substantia nigra pars reticulata interneuron GABA	fast-spiking interneuron	input resistance (MΩ)	313.0 ± 52.0 (48)	313.0 (MΩ)	Data Table
Neostriatum medium spiny neuron		membrane time constant (ms)	10.9 ± 0.72 (92)	10.9 (ms)	Data Table
Substantia nigra pars reticulata interneuron GABA	fast-spiking interneuron	membrane time constant (ms)	8.3 ± 0.9 (48)	8.3 (ms)	Data Table
Neostriatum medium spiny neuron		spike threshold (mV)	-27.0 ± 0.6 (92)	-27.0 (mV)	Data Table
Substantia nigra pars reticulata interneuron GABA	fast-spiking interneuron	spike threshold (mV)	-26.9 ± 0.9 (48)	-26.9 (mV)	Data Table
Neostriatum medium spiny neuron		spike amplitude (mV)	70.2 ± 0.9 (92)	70.2 (mV)	Data Table
Substantia nigra pars reticulata interneuron GABA	fast-spiking interneuron	spike amplitude (mV)	60.4 ± 1.5 (48)	60.4 (mV)	Data Table
Neostriatum medium spiny neuron		spike half-width (ms)	1.12 ± 0.04 (92)	1.12 (ms)	Data Table
Substantia nigra pars reticulata interneuron GABA	fast-spiking interneuron	spike half-width (ms)	0.65 ± 0.05 (48)	0.65 (ms)	Data Table
Neostriatum medium spiny neuron		AHP amplitude (mV)	14.3 ± 0.5 (92)	14.3 (mV)	Data Table
Substantia nigra pars reticulata interneuron GABA	fast-spiking interneuron	AHP amplitude (mV)	20.3 ± 0.8 (48)	20.3 (mV)	Data Table
Neostriatum medium spiny neuron		AHP duration (ms)	12.3 ± 0.5 (92)	12.3 (ms)	Data Table
Substantia nigra pars reticulata interneuron GABA	fast-spiking interneuron	AHP duration (ms)	4.1 ± 0.55 (48)	4.1 (ms)	Data Table