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Article: Spontaneous activity and properties of two types of principal neurons from the ventral tegmental area of rat.

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Koyama S; Kanemitsu Y; Weight FF
J. Neurophysiol., 2005



TABLE 2.Two types of ventral tegmental area (VTA) principal neurons
Cell Capacitance, pF Input Resistance, MΩ Action potential (AP)
Amplitude, mV Half-Width, ms Threshold, mV Peak AHP, mV AHP Decay Slope, mV/s
Irregular-type neurons 29.4 ± 2.1 (15) 896 ± 49 (19) 63.6 ± 1.2 (43) 3.8 ± 0.1 (43) –41.2 ± 0.7 (43) –60.1 ± 0.7 (43) 110.6 ± 11.0 (43)
Tonic-type neurons 24.2 ± 2.0 (20) 1097 ± 162 (14) 66.0 ± 1.7 (40) 3.3 ± 0.1 (40) –40.5 ± 0.5 (40) –67.9 ± 0.9 (40) 110.2 ± 8.8 (40)
P > 0.08 P > 0.2 P > 0.2 P < 0.0001 P > 0.4 P < 0.001 P > 0.9
All average values are expressed as means ± SE. Statistical comparison was done by Student’s t-test to assess significant differences. Cell capacitance was determined after the capacitative transients were cancelled. Membrane input resistance was determined by hyperpolarizing current pulses that induced a voltage shift of 10–15 mV negative to the resting potential, where the voltage-sag was not detected. AP half-width was measured half way between AP threshold and AP peak. AHP slope was measured by fitting a line from the AHP peak to the rising phase toward a subsequent AP spike. Numbers of neurons in parentheses.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Ventral tegmental area dopamine neuron Mesencephalon ventral tegemental area irregular-firing tyrosine hydroxylase-positive, glutamic acid decarboxylase-negative, calretinin-positive, parvalbumin-negative dopaminergic neuron cell capacitance (pF) 29.4 ± 2.1 (15) 29.4 (pF) Data Table
Ventral tegmental area dopamine neuron Mesencephalon ventral tegemental area irregular-firing tyrosine hydroxylase-positive, glutamic acid decarboxylase-negative, calretinin-positive, parvalbumin-negative dopaminergic neuron input resistance (MΩ) 896.0 ± 49.0 (19) 896.0 (MΩ) Data Table
Ventral tegmental area dopamine neuron Mesencephalon ventral tegemental area irregular-firing tyrosine hydroxylase-positive, glutamic acid decarboxylase-negative, calretinin-positive, parvalbumin-negative dopaminergic neuron spike amplitude (mV) 63.6 ± 1.2 (43) 63.6 (mV) Data Table
Ventral tegmental area dopamine neuron Mesencephalon ventral tegemental area irregular-firing tyrosine hydroxylase-positive, glutamic acid decarboxylase-negative, calretinin-positive, parvalbumin-negative dopaminergic neuron spike half-width (ms) 3.8 ± 0.1 (43) 3.8 (ms) Data Table
Ventral tegmental area dopamine neuron Mesencephalon ventral tegemental area irregular-firing tyrosine hydroxylase-positive, glutamic acid decarboxylase-negative, calretinin-positive, parvalbumin-negative dopaminergic neuron spike threshold (mV) -41.2 ± 0.7 (43) -41.2 (mV) Data Table
Ventral tegmental area dopamine neuron Mesencephalon ventral tegemental area irregular-firing tyrosine hydroxylase-positive, glutamic acid decarboxylase-negative, calretinin-positive, parvalbumin-negative dopaminergic neuron AHP voltage (mV) -60.1 ± 0.7 (43) -60.1 (mV) Data Table
Ventral tegmental area dopamine neuron Mesencephalon ventral tegemental area tonic-firing tyrosine hydroxylase-positive, glutamic acid decarboxylase-negative, calretinin-positive, parvalbumin-negative dopaminergic neuron cell capacitance (pF) 24.2 ± 2.0 (20) 24.2 (pF) Data Table
Ventral tegmental area dopamine neuron Mesencephalon ventral tegemental area tonic-firing tyrosine hydroxylase-positive, glutamic acid decarboxylase-negative, calretinin-positive, parvalbumin-negative dopaminergic neuron input resistance (MΩ) 1097.0 ± 162.0 (14) 1097.0 (MΩ) Data Table
Ventral tegmental area dopamine neuron Mesencephalon ventral tegemental area tonic-firing tyrosine hydroxylase-positive, glutamic acid decarboxylase-negative, calretinin-positive, parvalbumin-negative dopaminergic neuron spike amplitude (mV) 66.0 ± 1.7 (40) 66.0 (mV) Data Table
Ventral tegmental area dopamine neuron Mesencephalon ventral tegemental area tonic-firing tyrosine hydroxylase-positive, glutamic acid decarboxylase-negative, calretinin-positive, parvalbumin-negative dopaminergic neuron spike half-width (ms) 3.3 ± 0.1 (40) 3.3 (ms) Data Table
Ventral tegmental area dopamine neuron Mesencephalon ventral tegemental area tonic-firing tyrosine hydroxylase-positive, glutamic acid decarboxylase-negative, calretinin-positive, parvalbumin-negative dopaminergic neuron spike threshold (mV) -40.5 ± 0.5 (40) -40.5 (mV) Data Table
Ventral tegmental area dopamine neuron Mesencephalon ventral tegemental area tonic-firing tyrosine hydroxylase-positive, glutamic acid decarboxylase-negative, calretinin-positive, parvalbumin-negative dopaminergic neuron AHP voltage (mV) -67.9 ± 0.9 (40) -67.9 (mV) Data Table