P/Q-Type Currents | T-Type Currents in small IB4− TG Neurons | |||||
---|---|---|---|---|---|---|
V50,tail, mV | k, mV/e-fold change | n | V50,tail, mV | k, mV/e-fold change | n | |
EGFP | −47.36 ± 2.33* | 12.62 ± 2.31 | 16 | |||
hWT | −12.09 ± 3.53 | 6.34 ± 0.86 | 5 | −31.70 ± 1.78 | 12.37 ± 1.14 | 10 |
T666M | −12.53 ± 2.96 | 7.46 ± 2.46 | 5 | −44.53 ± 2.30* | 11.61 ± 2.36 | 12 |
-
Values are means ± SE; n, number of neurons. VGCC, voltage-gated Ca2+ channels; V50,tail, half-voltage of voltage-dependent activation calculated from tail current; k, slope factor; EGFP, enhanced green fluorescent protein.
-
↵* P < 0.01, compared with the human wild-type (hWT) group, one-way ANOVA with post hoc Bonferroni test.